The Causation Of Endometriosis Is A Subject Of Widespread Debate

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Endometriosis is a debilitating and painful disease estimated to occur in 50% of women seeking treatment for pain and infertility (Prince & Thomas, 2015). Despite its prevalence, there is a significant diagnostic delay associated with endometriosis; the length of time between the first presentation of symptoms to the actual diagnosis averages 6 to 11 years (Yates, 2015). This diagnostic delay stems from widely debated pathogenesis, varied presentation, and standard methods of diagnosis (Prince & Thomas, 2015; Vercellini, Vigano, Somingliana & Luigi, 2014; Yates, 2015).
Debated Pathogenesis
The causation of endometriosis is a subject of widespread debate (Prince & Thomas, 2015). Pathogenically, it is most widely evidenced and supported that reverse menstruation causes endometriosis (Vercellini et al., 2014). During reverse menstruation the endometrial lining flows up the oviducts and into the pelvic cavity (Vercellini et al., 2014). Once in the pelvic cavity the tissue embeds on and invades the surrounding organs (Vercellini et al., 2014). Risk factors for retrograde menstruation include genetic factors, early onset of menarche, and long menstrual flows (Vercellini et al., 2014). Conversely, opposing research discussed by Prince and Thomas (2015) suggests coelomic metaplasia as the cause for endometriosis. The theory of coelomic metaplasia refers to the epithelium that lines the abdominal membrane (Prince & Thomas, 2015). During coelomic metaplasia the skin cells…

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