When cortisol levels are too high for too long, they can cause these neurons to lose synaptic connections, so they can’t turn off the stress response and stress hormone/cortisol levels stay high (Randall). The body stays at this heightened level of stress. But that’s not it - besides the hippocampus, two other brain areas respond to high cortisol levels in maladaptive ways. The amygdala, which is a critical area for detecting and organizing reactions to threat, responds to the large amounts of norepinephrine and cortisol by working better. So when someone encounters something that may or may not be an actual threat, there is a high propensity to engage the stress
When cortisol levels are too high for too long, they can cause these neurons to lose synaptic connections, so they can’t turn off the stress response and stress hormone/cortisol levels stay high (Randall). The body stays at this heightened level of stress. But that’s not it - besides the hippocampus, two other brain areas respond to high cortisol levels in maladaptive ways. The amygdala, which is a critical area for detecting and organizing reactions to threat, responds to the large amounts of norepinephrine and cortisol by working better. So when someone encounters something that may or may not be an actual threat, there is a high propensity to engage the stress