Insulin resistance

More than 29.1 million people in the United States have diabetes. Diabetes is a condition in which the body does not make or correctly use the hormone insulin. Without insulin, sugar can’t get into the cells where it’s needed in the body. Instead, it stays in the blood, causing blood sugar to rise. Aside from affecting the person’s blood sugar, diabetes also can cause digestive issues, cardiovascular problems, skin and eye conditions, and nerve damage. Many people with diabetes are taking…

Objectives: To evaluate the association of glutathione S- transferase mu 1 (GST M1) and glutathione S- transferase theta 1 (GST T1) polymorphisms with the development of T1DM and disease-related risk factors. Materials and Methods: The study included 64 diabetic children with T1DM and 41 control subjects. They were subjected to: history taking anthropometric measurements and laboratory parameters included fasting glucose, serum creatinine, lipid profile, HbA1cand evaluation of GST T1 and M1…

cytokine exclusively produced and secreted by adipocytes. In mice, adiponectin decreases hepatic lipogenesis and increases FFA oxidation. In humans, several studies have shown an inverse correlation between adiponectin levels in the blood and hepatic insulin sensitivity as well as fat content in the liver. Adiponectin is a cytokine which acts as an anti-steatotic factor in both muscle and hepatocytes, probably by activating Peroxisome proliferator-activated receptor gamma (PPARγ) and…

diabetes, also known as insulin-dependent diabetes, the body's immune system kills the cells that release insulin, eventually eliminating insulin production. Without insulin, cells cannot absorb sugar (glucose), which is needed to produce energy. Type 2 diabetes, or also known as non-insulin dependent diabetes, the body isn't able to use insulin, or what is called insulin resistance. As type 2 diabetes progresses, the pancreas may make less and less insulin, which can lead to insulin deficiency.…

perpetual battle with insulin. An essential hormone manufactured by the pancreas, insulin plays an important role in absorbing glucose from foods we eat to convert to energy. Failure of the body to use insulin effectively could lead to insulin resistance which is a precursor to prediabetes, diabetes and other serious conditions. As a result, more insulin is built up to stabilize blood sugar from spiraling out of control. The cells stop responding to signals, making it €insulin-resistant€. Most…

Diabetes mellitus is classified into two types: type 1 diabetes mellitus, in which there is a total destruction of beta cells, which leads to absolute insulin deficiency; and diabetes mellitus type 2 or non-insulin, a consequence…

Study two shows that they do not relate to insulin resistance. Study 2 analyses the insulin sensitivity levels that are affected by AdipoR1 and AdipoR2 and how they are affected by the age and racial features of a study cohort (Peters, K et al. 2013). Study 2 does not discuss the SNPs’ links to type 2 diabetes in detail…

the seventh leading cause of death (Centers for Disease Control and Prevention, 2016). Diabetes type 2 has almost doubled in the past two decades and it is more common than type 1 diabetes. Type I diabetes patients do not produce insulin but type 2-diabetes produce insulin but not enough for the body’s needs. The topic that the author chose is diabetes mellitus type 2. This article will include pathophysiology, disease process, treatments, and follow up plan. Pathophysiology of diabetes type 2…

causes type 2 diabetes? Eating too much and exercising too little can increase the risk for developing type 2 diabetes. Insulin is a hormone made in the pancreas, which allows glucose (sugar) to leave the bloodstream and enter the cells to be used as fuel. Going from type 2 diabetes when the pancreas does not make enough insulin or the body's cells become resistant to insulin. It is not known for sure why some people develop type 2 diabetes and others do not. There are many factors, however,…

dramatically decreases the production of insulin. The two main problems related to insulin in type 2 diabetes are insulin resistance and impaired insulin secretion. Insulin resistance refers to a decreased tissue sensitivity to insulin. Normally, insulin binds to the cell receptors and initiates a series of reaction involved in glucose metabolism. In type 2 diabetes, these intracellular reactions are diminished, thus rendering insulin less effective…