Insulin resistance

Diabetes Mellitus Type 2 is a complex chronic metabolic disorder characterised by increased insulin resistance and impaired insulin secretion by pancreatic beta cells and involving an interplay of various genetic and environmental factors. This report discusses the pathogenesis and long term complications of type 2 diabetes as well as several pharmacological treatments. Pathogenesis of Type 2 Diabetes
Genetic predisposition contributes to the pathogenesis of Type 2 diabetes as evidenced by a…

According to (Narayan et al,2000), Type 2 diabetes is a very common chronic illness suffered by 2.5 million people in UK. The concerning figures of diabetes are estimated to increase by 42% in industrialised countries and 170% in industrialising countries between 1995 and 2025 (Narayan et al,2000). In this essay I will be discussing about the the relationship between obesity and type 2 diabetes, genetic susceptibility towards causing type 2 diabetes and effects of obesity on the functioning of…

chronic hyperglycaemia with disruption of carbohydrate, fat and protein metabolism. The elevation of blood glucose level is due to defects in insulin secretion, impaired insulin action, or both. Diabetes mellitus is categorized to type 1 and 2. Type 1 diabetes mellitus (T1DM) usually develops in childhood and adolescence. The patients need to rely on insulin injections lifelong for survival. Whereas Type 2 diabetes mellitus (T2DM) usually develops in adulthood and it is related to some…

impervious to insulin, which implies that body cells don 't react fittingly when insulin is available. Dissimilar to type 1 diabetes, the insulin resistance is for the most part "post-receptor", significance it is an issue with the cells that react to insulin instead of an issue with creation of insulin (Vijan, 2010). Since sugar is not getting into the tissues, strangely elevated amounts of sugar develop in the blood, which is called hyperglycemia. Numerous individuals with insulin resistance…

squats, bench press, deadlifts, etc.  Interval resistance training  ESTROGEN Estrogen is the primary hormone for the female body, but both men and women require this hormone to properly function. We often assume that men have no need for estrogen, but on the contrary it is very much required to keep…

Metabolic shifts during trauma/sepsis occur to oblige the body’s need for increased energy. This results in high levels of glucose, fatty acids (FA), and amino acids (AA) circulating in the blood. Simultaneously, the inflammatory response induces insulin resistance, preventing the body from using this fuel and driving septic persistence. Changes in the functionality of fat stores during sepsis may mediate…

Diabetes and hypertension is a prevalent, worldwide epidemic that is on the rise. Everyday, more and more people are diagnosed with diabetes mellitus (DM) or hypertension (HTN); at times, some patients are diagnosed with both. In 2012, 1.7 million new cases were diagnosed among people who are aged 20 years or older in the United States. According to the CDC 2014 National Diabetes Statistics Report, 29.1 million or 9.3% of the United States population have diagnosed or undiagnosed diabetes. In…

ovarian syndrome (aka PCOS) is a disorder that is expected in patients with irregular menses, acne, seborrhea, hirsutism, infertility, and alopecia. PCOS has recently been associated with the metabolic syndrome. Patients may develop obesity, insulin resistance, type 2 diabetes, hypertension, liver disease, and sleep apnea. Clinical diagnosis would include hematological and radiological tests. Management would be a combined effort between a patient’s dermatologist, endocrinologist, gynecologist,…

Abstract Type 2 Diabetes is a disease that is normally characterized by how the body has a lack of sensitivity to insulin and how the cells bind to the insulin, this causes a person’s response to glucose to change. The glucose levels in diabetics are much higher than the average person due to the lack of sensitivity that they have to insulin. In this experiment, we tested the hypothesis that people who are diabetic will have a higher blood glucose concentration and light absorbance than…

If you are overweight, a diabetic, suffer from insulin resistance, or suffer from metabolic syndrome, we have news to share with you regarding conventional medicine and diabetes. Conventional medicine just may be making your condition worse. In fact, lowering your blood sugar may actually increase your risk of death. Findings in The New England Journal of Medicine indicates that treatment with conventional medicine for your elevated blood sugar levels may be doing you more harm than good.…