Phamacology Chapter 5 Pharmacodynamics

Front 1

agonist

Back 1

agent that is capable of binding with receptors and producing a response

Front 2

antagonist

Back 2

agent that blocks the response of another drug

Front 3

dose-response relationship

Back 3

the way a patient responds to varying doses of a drug

Front 4

efficacy

Back 4

the maximal response that can be produced from a particular drug

Front 5

frequency distribution curve

Back 5

a graphic representation of the actual number of patients responding to a particular drug action at different doses

Front 6

idiosyncratic response

Back 6

unpredictable and unexplained drug reaction

Front 7

intrinsic activity

Back 7

the ability of a drug to bind to a receptor and produce a strong action

Front 8

median effective dose (ED50)

Back 8

the dose of a drug required to produce a specific therapeutic response in 50% of a group of patients

Front 9

median lethal dose (LD50)

Back 9

the dose of a drug that will kill 50% of a group of animals

Front 10

median toxicity dose (TD50)

Back 10

dose that will produce a given toxicity in 50% of a group of patients

Front 11

partial agonist

Back 11

medication that produces a weaker, or less efficacious, response than an agonist

Front 12

pharmacodynamics

Back 12

study of the mechanisms of drug action and how the body responds to drugs

Front 13

pharmacogenetics

Back 13

the study of genetic variations that give rise to differences in the way patients handle medications; branch of pharmacology that examines the role of genetics in drug response

Front 14

potency

Back 14

the strength of a drug at a specified concentration or dose

Front 15

receptor

Back 15

the structural component of a cell to which a drug binds to produce a response

Front 16

second messenger

Back 16

cascade of biochemical events that initiates a drug's action by either stimulating or inhibiting a normal activity of the cell

Front 17

therapeutic index

Back 17

the ratio of a drug's LD50 to its ED50