Pharmacology Chapter 17 Cholinergic Agonists

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acetylcholinesterase (AchE) inhibitor

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indirect-acting cholinergic agonist that is nonselective and affects all Ach synapses

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cholinergic agonist

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drugs and chemicals that increase the action of acetylcholine (Ach) at a cholinergic receptor; also called a parasympathomimetic

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cholinergic crisis

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caused by an overdosage with acetylcholinesterase (AchE) inhibitors or poisoning with organophosphate insecticides or toxic nerve gases; characterized by intense signs of parasympathetic stimulation such as miosis, nausea, vomiting, urinary incontinence, increased exocrine secretions, and abdominal cramping

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muscarinic agonist

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drug that is selective for muscarinic receptors

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myasthenia gravis (MG)

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muscular disorder caused by a destruction of nicotinic synapses on skeletal muscles and characterized by extreme fatigue, double vision, speech impairment, and difficulty chewing or swallowing

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myasthenic crisis

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extreme muscular weakness and symptoms similar to those of cholinergic crisis; caused by abrupt discontinuation of medication for myasthenia gravis

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nicotinic agonist

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drug that is selective for nicotinic receptors

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reflex tachycardia

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temporary increase in heart rate that occurs when blood pressure falls

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Sjšgren's syndrome

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chronic autoimmune disorder characterized by excessive dryness of mucous membranes

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xerostomia

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dry mouth