Classification Of Antagonists Essay

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This essay illustrates the classification of antagonists according to their characteristics. The classification of antagonists is divided into two main categories, receptor antagonists and non-receptor antagonists. In receptor antagonists, it would be divided into competitive antagonists and non-competitive antagonists. In non-receptor antagonists, divided into chemical antagonists and physiological antagonists. In different categories, there are different examples to support the feature of the corresponding classification.

In clinical practice, there are many kinds of antagonists that can be used to treat different diseases. To understand the classification of antagonists is the premise of using them. The purpose of this essay is to analyze
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A non-competitive antagonist binds different active sites with a receptor from an agonist, forms a covalent bond or high affinity with receptor (Golan et al., 2012). If the binding way of noncompetitive antagonists is to form active sites with receptor, it is usually irreversible. Although non-competitive antagonists and agonists do not compete for the same receptor, non-competitive antagonists prevent agonists from binding to receptors. Another situation is, noncompetitive antagonists compete with agonists for the same receptor, but prevents agonists binding with receptors due to covalent bonds Binding way (Golan et al., 2012). The specific example is Verapamil, which is a calcium channel blocker. Verapamil binds to a specific site on the surface of cytoplasmic end, thereby blocking the influx of Ca+( Andersen et al., 2006). Verapamil is able to treat related diseases in the range of 10-20 micromolar (Fleckenstein, 1988). It is used in the high risk of diseases such as angina, hypertension and …show more content…
The function of antagonists is to inhibit agonists and thereby bind to receptors. According to whether antagonists bind to receptors, this essay is divided into two main categories, receptor antagonists and non-receptor antagonists. A receptor antagonist is capable of binding to a receptor and has a different effect on an agonist. Depending on whether they compete with agonists, antagonists are divided into competitive antagonists and non-competitive antagonists. In competitive antagonists, naloxone is an opioid receptor antagonist. It is able to compete for opioid antagonism under stress conditions, and would treat acute poisoning and anti-sedation. In non-competitive antagonists, vipyrone is belong to calcium antagonists, inhibit myocardial excitability and atrioventricular conduction. It could treat acute and chronic coronary artery insufficiency or angina pectoris. In non-competitive antagonists, there are divided into reversible and irreversible. Antagonists have other way to inhibit agonist in despite of not binding to receptors. According to the effect of non-receptor antagonists in the body, they are divided into chemical antagonists and physiological antagonists. In chemical antagonists, thiol-containing chelators are able to displace heavy metals from biological ligands. The action of this chemical antagonist reduces the toxicity of heavy metals in the body. In physiological

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