Costus speciosus (J.König)sm is a widely used medicinal plant in Ayurvedic medicine. Scientific literature prove about various therapeutic properties of its rhizome and leaves. The effectiveness of Costus speciosus (J.König)sm leaf aqueous extract on reversing insulin resistance was studied and data were published previously. This study was designed to evaluate the dose-response relationship of Costus speciosus (J.König)sm leaf aqueous extract. Insulin resistance induced rats were treated with 1500, 2000, 2500 and 3000 mg/kg doses of Costus speciosus (J.König)sm leaf aqueous extract for 12 weeks. Fasting serum glucose, triglyceride and insulin were analysed at baseline, 4, 6, 8 and 12 weeks of therapy. The three insulin resistant indices Homeostasis Model Assessment (HOMA), Quantitative Insulin sensitivity Check Index (QUICKI) and McAuley Index (McA) were calculated and quantal dose-response graphs were drawn. All
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It determines the extent to which the desired response of a drug alter at differing levels of doses after a particular period of exposure [9]. Mainly, dose-response relationships are in two types known as graded and quantal in nature [9]. Graded dose-response (GDR) curve relates the dose to the intensity of the effect. Also, the response is measured in a continuous and gradual scale against the increasing dose [9,10]. Quantal dose-response (QDR) curve is built upon 'all or none' principle and the curve plots the cumulative percentage of a population responding to a specified drug effect versus dose.[9] The studies on dose-response relationships help to assess both qualitative and quantitative characteristics of a drug. In addition, they are important for determination of therapeutic doses, precise dose adjustments and to avoid toxicity due to higher doses. Therefore, a detailed dose-response study is a premier requirement to understand the pharmacodynamic properties of a
It determines the extent to which the desired response of a drug alter at differing levels of doses after a particular period of exposure [9]. Mainly, dose-response relationships are in two types known as graded and quantal in nature [9]. Graded dose-response (GDR) curve relates the dose to the intensity of the effect. Also, the response is measured in a continuous and gradual scale against the increasing dose [9,10]. Quantal dose-response (QDR) curve is built upon 'all or none' principle and the curve plots the cumulative percentage of a population responding to a specified drug effect versus dose.[9] The studies on dose-response relationships help to assess both qualitative and quantitative characteristics of a drug. In addition, they are important for determination of therapeutic doses, precise dose adjustments and to avoid toxicity due to higher doses. Therefore, a detailed dose-response study is a premier requirement to understand the pharmacodynamic properties of a