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22 Cards in this Set

  • Front
  • Back
True or false: in some cases, T cells bind antigens not presented by ther cells, but rather floating in solution
False; they require presentation
What are the types of APC?
1) Monocytes/macrophages
2) B cells
3) Dendritic cells
What APC takes up materials by pinocytosis?
Dendritic cells
True or false: B cells recognize denatured protein antigen, whereas T cells recognize initial, in-tact antigen
False; the opposite is true.
What T cell marker is associated with MHC class I?
CD8+; this is associated with killing cells; want to kill cell when it has endogenous antigen, which is implied by MHC class I
What T cell marker is associated with MHC class II?
How does Ig opsonization improve phagocytosis for macrophages? C3b opsonization?
When opsonization occurs with an Ig, the macrophage binds the Fc domain and then eats the cell. There is also a C3b receptor.
True or false: strong immunogens bind MHC molecules worse than weak immunogens
False; they bind better, which is logical
True or false: one MHC molecule recognizes one epitope
False; each MHC molecule can recognize a range of epitopes; this increases the repertoire of MHC molecules
What family of proteins is responsible for transporting antigen peptides into teh RER? What specific proteins?
The ABC protein family; TAP-1 and TAP-2 are the specific proteins
What does li tand for? What does li do?
The invariant chain; li is attached to MHC class II until it reaches the lysosome; li is swapped for antigen peptide
True or false: MHC class II molecules are synthesized in the RER, then they go directly to the lyosome to combine with antigens
False; they first go to the golgi apparatus, which directs them to teh lysosome
True or false: antigens that bind to MHC class II never enter the RER
True; they enter the cell in a phagosome, which fuses with a lysosome; this is the lysosome where combination with MHC class II occurs
What is one factor that leads to an increase in MHC class II molecules on the cell surface?
CD4 is a ligand for what? Seen on what cell type? What is the basic function?
This is a ligand for MHC class II; involved in cell-cell adhesion and signal transduction
CD8 is a ligand for what?
Class I MHC molecules
What cell is ICAM-1 seen on? What does it bind?
ICAM-1 is seen on APCs; it binds LFA-1.
What cell type is CD2 seen on? What does it bind?
It is seen on T cells, which makes sense since CD4 and CD8 are on T cells. It binds LFA-3
What are lr genes also called? What do they encode?
Also called immune response genes.
True or false: immune response genes are inherited at the class I loci of the MHC
False; class II loci
What genes dictate the specificity of the MHC molecules?
The immune response (lr) genes
What is the theory of determinant selection?
Some antigens cannot be recognized because a matching MHC does not exist; may have correct T cell, but it cannot be activated