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22 Cards in this Set

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True or false: in some cases, T cells bind antigens not presented by ther cells, but rather floating in solution
False; they require presentation
What are the types of APC?
1) Monocytes/macrophages
2) B cells
3) Dendritic cells
What APC takes up materials by pinocytosis?
Dendritic cells
True or false: B cells recognize denatured protein antigen, whereas T cells recognize initial, in-tact antigen
False; the opposite is true.
What T cell marker is associated with MHC class I?
CD8+; this is associated with killing cells; want to kill cell when it has endogenous antigen, which is implied by MHC class I
What T cell marker is associated with MHC class II?
CD4+
How does Ig opsonization improve phagocytosis for macrophages? C3b opsonization?
When opsonization occurs with an Ig, the macrophage binds the Fc domain and then eats the cell. There is also a C3b receptor.
True or false: strong immunogens bind MHC molecules worse than weak immunogens
False; they bind better, which is logical
True or false: one MHC molecule recognizes one epitope
False; each MHC molecule can recognize a range of epitopes; this increases the repertoire of MHC molecules
What family of proteins is responsible for transporting antigen peptides into teh RER? What specific proteins?
The ABC protein family; TAP-1 and TAP-2 are the specific proteins
What does li tand for? What does li do?
The invariant chain; li is attached to MHC class II until it reaches the lysosome; li is swapped for antigen peptide
True or false: MHC class II molecules are synthesized in the RER, then they go directly to the lyosome to combine with antigens
False; they first go to the golgi apparatus, which directs them to teh lysosome
True or false: antigens that bind to MHC class II never enter the RER
True; they enter the cell in a phagosome, which fuses with a lysosome; this is the lysosome where combination with MHC class II occurs
What is one factor that leads to an increase in MHC class II molecules on the cell surface?
Interferon-gamma
CD4 is a ligand for what? Seen on what cell type? What is the basic function?
This is a ligand for MHC class II; involved in cell-cell adhesion and signal transduction
CD8 is a ligand for what?
Class I MHC molecules
What cell is ICAM-1 seen on? What does it bind?
ICAM-1 is seen on APCs; it binds LFA-1.
What cell type is CD2 seen on? What does it bind?
It is seen on T cells, which makes sense since CD4 and CD8 are on T cells. It binds LFA-3
What are lr genes also called? What do they encode?
Also called immune response genes.
True or false: immune response genes are inherited at the class I loci of the MHC
False; class II loci
What genes dictate the specificity of the MHC molecules?
The immune response (lr) genes
What is the theory of determinant selection?
Some antigens cannot be recognized because a matching MHC does not exist; may have correct T cell, but it cannot be activated