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67 Cards in this Set

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Metabolism

sum total of what (chemical reactions) that go on in the cell

Aerobic

requires oxygen for reaction

anaerobic

not requiring oxygen

Deamination

removal of the amino (NH3) group from a compound such as amino acids

ATP

Adenosine triphosphate. A high energy compound made from purine (adenine), a sugar (ribose) and 3 phosphate groups. ATP=A-P~P~P where ~ indicates a high energy bond in between the phosphates. Primary molecule used for energy. The body's currency for energy.

ATP is released from:

the breakdown of glucose (carb), fatty acids (fats and glycerol) and amino acids (protein), the end products of digestion. Has a negative charge and is vulnerable to hydrolysis.

Pyruvate

a 3 carbon compound that plays a key role in energy metabolism

Acetyl CoA

a 2 carbon compound (acetate or acetic) to which a molecule of CoA is attached

Gluconeogenesis

the making of glucose from a non-carbohydrate source such as amino acids or glycerol

Ketone Bodies

acidic compound produced by the liver during the incomplete breakdown of fat when carbohydrates are not available.

What are coenzymes? Why do you need them in metabolism?

Coenzymes are organic molecules that work with enzymes (make metabolic reactions) to facilitate the enzymes activity; enzymes cannot function without coenzymes. Many have A and B vitamins as part of their structure.

What four basic units are used in the body for energy metabolism?

carbs make glucose, fats make fatty acids and glycerol, and proteins make amino acids.

What is the powerhouse of the cell?

the mitochondria

what are characteristics and metabolism?

Canabolism builds body compounds (skeletal, lipoproteins, hormones, etc) which requires energy. Catabolism breaks down body components such as lactase breaking into glucose and galactose. This releases energy. Think house building requires energy (anabolsim). house catching fire requires no energy and destroys and also releases heat (energy) (catabolism).

Howefficient is the body at converting food energy to ATP energy?

About a 50% rate of conversion. The rest is lost as heat.

What is the major energy carrier molecule in most cells?

ATP

Glycolysisis the conversion of glucose to:

2 pyruvate

Whatare some differences between aerobic and anaerobic exercises?

Anaerobic exercise would be a quick and vigorous exercise where oxygen is not readily available to make energy and the process would take too long and the energy needs are more immediate during this type of exercise. This type of energy yielding pathway, pyruvate to lactate, cannot be sustained for very long, only for a couple of minutes. When energy needs are at a slower pace, such as endurance cardio exercise, pyruvate can take a slower pathway to make energy, pyruvate to acetyl CoA. The energy yielded is greater and can be sustained longer.

Whatcan happen to lactate after being produced by muscle cells?

The lactate can be sent to the liver.

Whathappens in the Cori Cycle?

The lactate from the muscles go to the liver and can be converted into glucose.

Howmany acetyl CoA molecules would be obtained from a 16-carbon fatty acid?

1Acetyl CoA from a 16-carbon fatty acid. The fatty acids carbon chain goesthrough the cycle numerous times and loses 2 carbons each time. 8 acetyl CoA isnet yield from 1 whole 16-carbon fatty acid.

Wheredo the TCA cycle reactions occur?

Thiscycle is the final common metabolic pathway for carbs, fats, and amino acids.It takes place in the mitochondria’s inner compartment.

Which energy yielding nutrients, when consumed in excess, can lead to the storage of fat?

All of the energy yielding nutrients leas to storage of fat (carbs, lipids, and proteins)

What substances can be converted to glucose if carbohydrate is lacking in the diet?

Glycerol (1st choice) and proteins as amino acids (last resort)

Besides energy, what is given off following the complete oxidation of fatty acids?...Glucose?

water and CO2

What is the body's major metabolic organ?

Liver

What are the effects of the accumulation of lactate in the muscles?

The lactate accumulation in the muscles can lead to sore muscles, cramps, fatigue, and a change in the PH because lactate is acidic. Interestingly, anaerobic exercise can increase mitochondria size over time so it can produce more energy.

How many pyruvate and acetyl CoA does one molecule of glucose yield?

2 pyruvate which will yield 2 acetyl CoA when coenzymes are added.

Explain what happens during feasting.

Duringfeasting a person is eating more than their energy needs so the body stores asmall amount as glycogen and the rest as fat. Carbohydrates get stored as glycogenand body fat. Fat gets stored as fat. Protein gets stored as fat, some is lostin the urine and used as body protein

Explain what happens during fasting.

Duringfasting the nutrients from a meal are no longer available (2 to 3 hours)and thebody beings to draw on its glycogen and fat stores for energy. Liver and muscleglycogen stores get broken down into glucose and the energy is used for thebrain, nervous system, and red blood cells as well as other cells. Body fatstores are broken down into fatty acids and used for energy for other cells.

Explain what happens during fasting beyond glycogen depletion.

.Fasting beyond glycogen depletion (starvation after 24 hrs) glycogen hasdwindled and the body beings to break down its proteins (from muscles and leantissue) to amino acids to make glucose needed for the brain and nervous system.The liver converts fats to ketone bodies, which serve as an alternate energysource for the brain which slows down the breakdown of body protein.

During a prolonged fast, what alternative fuel does the brain begin to accept?

amino acids and glycerol. Ketone bodies as a last resort.

Where does the metabolism of alcohol take place?

the liver

How can alcohol consumption affect nutritional status?

Can cause malnutrition: low intakes of protein, calcium, iron, vitamin A, Vitamin C, thiamin, vitamin B, and riboflavin, impaired absorption of calcium, phosphorus, vitamin D and zinc. Increases energy intake which can lead to obesity, can cause liver disease which can hurt metabolism and food absorption and energy usage.

Appetite

response to the thought, sight, smell, or taste of food that initiates or delays eating

hunger

the painful sensation caused by a lack of food that initiates food seeking behavior. Physiological response to nerve signals and chemical messengers sent by the hypothalamus.

Satiety

signal to not start eating again

visceral fat

fat stored within the abdominal cavity in association with the internal abdominal organs.

Central obesity

upper body fat.

Based on the traditional calculation, how many kcalories are equal to 1 pound of body fat?

1 pound of fat = 3500 kcal. Extra 500 kcal for a week could make a person gain a pound of fat.

What role does the hypothalamus play in energy balance?

It is the control center for eating and it integrates messages for energy intake, expenditure, and storage. Produces the sensation of hunger. Produces hormones to initiate hunger sensations. Senses satiety and sends signals to stop or continue eating.

What are the 3 components of energy expenditure? Which one is the greatest expenditure for sedentary individuals? Which one is the most variable? Which one accommodates for only a small portion of energy expended?

BasalMetabolism, Physical activity, and Food Consumption. Basal Metabolismrepresents 2/3 of daily energy for sedentary or light activity. Physicalactivity is the most variable because it is voluntary movement of skeletalmuscles. Food consumption has a small thermic effect that uses roughly 10% ofenergy intake. High protein diets use more energy.

Whatis basal metabolism? What factors affect basal metabolic rate?

The energy needed to maintain life when a body is at complete digestive, physical and emotional rest. Genetics, Age, activity level, hormones, growth, gender, weight, and amount of lean tissue (uses more energy) can affect BMR.

Whatis the formula for calculating body mass index? Calculate BMI when given aperson’s weight and height.

Weight in kg/height (in meters)2 = BMI or weight in pounds/height (in inches)2 x 703 =BMI

Underweight

body weight lower than weight range that is considered healthy, less than BMI of 18.5.

Overweight

body weight greater than the weight range that is considered healthy, BMI of 25-29.9

Obese

too much body fat with adverse health effects, BMI of 30 or more.

Howdoes fat distribution in the body affect health risk?

Correlates with but not always the cause of disease and lower life expectancy. Weight around middle (above waist) has more risks of chronic diseases, especially heart disease. Visceral fat (near organs) can have effects on health and lead to liver and heart disease.

Forwhat purpose is waist circumference measured? What are the desirablemeasurements for women?...for men?

It is an indicator of fat distribution and central obesity. Women should haveunder 35 inches and men should have under 40 inches

Whatare some methods of measuring body fat?

BMI and waist circumference are the most common. Other include skin fold, displacement (bod pod) and DEXA for more precise measurement.

Whathealth risks are associated with being underweight?...overweight?

Obesity is designated as a disease because of the health risks associated such as cardiovascular disease, elevated blood cholesterol, hypertension, diabetes (especially with central obesity), and some cancer. Underweight risks are fighting against wasting disease, menstrual irregularities and infertility (self-preservation) and osteoporosis and bone fractures. A change in the body’s metabolism has a cluster of symptoms: insulin resistance, high blood glucose, low HDL, hypertension, high triglycerides, and greater risk for diabetes, cancer, heart disease, strokes, and atherosclerosis. This is due to inflammation in body when there is fat accumulation, which causes the body to panic.

Amenorrhea

the absence of or cessation of menstruation. Primary amenorrhea is menarche delayed beyond 15 years of age. Secondary amenorrhea is the absence of 3 consecutive menstrual cycles.

Cathartic

a strong laxative

emetic

an agent to induce vomiting

Female athlete triad

apotentially fatal combination of three medical problems: disordered eating,amenorrhea, and osteoporosis

Whatpercentage of adults in the United States are considered overweight or obese?

69 %

Whatpercentage of children in the United States are considered overweight or obese?

32 percent

Whatis lipoprotein lipase? (What role does it play in the development of obesity)?

Allows fatty acids (fat) to move from the bloodstream into fat cells. As weight is gained, there is more of that activity and the body beings to favor fat.

Describefat cell development. (What happens to the fat cells when a person losesweight?)

Fat cells can grow and enlarge. When weight is lost the size of the fat cell will shrink but the number of fat cells stay the same. When energy in exceeds energy out the adipose tissues store the excess as fat cells. Fat cell number increase during childhood and adolescence

Set-pointtheory

the body attempts to maintain a certain weight. If it falls below point thebody tries to get it back up to a certain weight by using less energy(calories) in daily use. If it rises the body tries to get it lower by suppressingappetite or using more energy in activities

Leptin

acts as a hormone in the hypothalamus. It is created in the adipose tissue and promotes a negative energy balance (take in less energy than expending). It also brings down appetite, increases calories burned and increases energy expenditure. Leptin Lose Weight.

Ghrelin

secretedby the stomach walls. It increases appetite and positive energy balance (takein more calories than expending). Ghrelin Gain Weight

Describefactors that influence the development of obesity (genetics and environment).

Obesity reflects the interaction between genes and environment. Present and past eating habits and activity patterns can influence current weight. The availability of food is another factor leading to general obesity since it is more accessible and can be relatively inexpensive. Serving sizes have also increase and the body equates what you normally eat to what a normal meal will be over time. Life requires little exertion now which modern conveniences which has decreased physical activity.

What3 indicators do health care professionals use to evaluate health risks fromobesity?

BMI, waist circumference, and disease risk profiling

Weight loss would be recommended for people who are overweight and have chronic disease risk factors of?

Hypertension, cigarette smoking, abnormal blood lipids, diabetes or prediabetes, family history of heart disease, men over 45 or women over 55.

Whataggressive treatments for obesity are being used? When are these appropriate?

Prescription drugs are available for weight loss in severe cases. They have many side effects, however, and the risks must be taken into account. Surgery such as gastric bypass and gastric banding may also be used but these also have risks and patients have to stick to a very specific eating plan afterwards.

Explainappropriate weight loss strategies.

Set a reasonable goal, such as losing 0.5 to 2 pounds a week. A person must embrace changes, celebrate success, set a goal, and have support. Incorporate healthy eating and physical activity. Consume food and drink to meet or get below energy needs for the day. East slowly, emphasize nutrient dense food, plan meals, limit sugars and fats, reduce portions, cook more and eat out less.