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20 Cards in this Set

  • Front
  • Back
Describe anisocytosis
red cells varying widely in size
Describe microcytosis. Associated with what 3 pathologies?
red cells that are too small.

Iron deficiency
sideroblastic anemia
mean corpuscular volume
Describe macrocytosis and its associated pathologies.
Large red cells.

Associated with:
elevated reticulocyte ct (more released, avg MCV goes up)
liver disease (makes too much membrane)
B12/folate deficiency
thyroid disease
anti-retrovirals (all changes in DNA synthesis)
Describe hypochromasia. How do you measure?
Red cells that have too little hemoglobin
(central pallor is more than 1/3)

measured by MCH
Describe polychromasia. Which cells are likely to have this characteristic?
Red cells that have more of a bluish tinge.
Probably reticulocytes
Describe poikilocytosis.
Red cells that vary widely in shape.
Associations of Target RBCs.
liver disease (more membrane)
Hemoglobin C
After splenectomy
Describe spherocytes. Associations?
Loss of central pallor.
Seen in:
hereditary spherocytosis
autoimmune hemolysis
Differentiate spherocytes v. schistocytes.
Schistocytes have sharp edges

Associated with
Microangiophatic Hemolytic Anemia (MAHA)
What is present in echinocytes? How are these different from acanthocytes?
Small regular projections in echinocytes
-seen in renal disease
Acanthocytes are much more irregular
-seen in liver disease
When are teardrop cells seen?
myelophthisic processes (diseases of marrow infiltration)

Seen in:
-tumor metastatic to marrow
-granulomatous diseases
-leukemias and lymphomas
-massive splenomegaly

(things in the bone marrow)
Peripheral, small, round, purple inclusions within red cells that represent nuclear remnants; seen when?
Howell-Jolly bodies; after splenectomy

(can go away after splenic re-growth)
What is visible after splenectomy?
Howell-Jolly bodies, target cells, acanthocytes, schistocytes, nucleated red cells
Linear arrangements of red cells?
Seen when?
Rouleaux; "piles of coins on a plate"
Inc levels of Ig, such as multiple myeloma or Waldenstrom's macroglobulinemia
Agglutination occurs when?
Coated with IgM
Hypochromic, microcytic cells seen when?
Iron deficiency anemia (also inc platelets)
5 pieces present in B-thalassemia major
target cells
Howell-Jolly bodies
Nucleated red cell
Basophilic stippling
(maybe teardrops too)
2 things seen in megaloblastic anemia sometimes
macrocytic red cells
hypersegmented neutrophils (high yield)
Components of Autoimmune Hemolytic Anemia