Hematotoxicity Experiment

First, hematotoxicity is the study of blood and blood-forming tissues as a target organ for drugs or different chemicals. It is the toxic effect that the substance has on the properties or components of blood. Additionally, other factors to include when determining toxicity are stress, exercise, and ionizing radiation. Furthermore, blood and hematopoietic tissue are target organs for scrutiny and the study in preclinical and clinical safety evaluations.
There are several methods that researchers can use when conducting tests on drugs and substances. The hematotoxicity testing will be dependent on if the drug is actively administrated to patients who had reactions or if the drug is still in the discovery phase.
A controversial issue is the
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The erythrocyte carries the pigment that makes the reddish color of the blood due to the pigment hemoglobin being present. Also, the hemoglobin concentration needs to be tested as well as the hematocrit or the packed cell volume. Essentially, it is the volume percentage of red blood cells in the blood. Additional testing would be required for the total leukocyte count, which is referred to the white blood cell count. The thrombocyte count is another integral test to determine the possibility of hematotoxicity. It is just another term for platelet and it functions in the clotting of the blood.
A few of the other tests include peripheral blood cell morphology, bone marrow cytology using the smear method, Also, a bone marrow histology and screening using coagulation tests. These tests are considered the core tests needed to determine hematotoxicity. There are other tests that could be conducted when special problem driven tests are needed. These tests will go into more detail in an attempt to determine the hematotoxicity of a substance in a human or cross
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The reticulocyte count determines how fast the red blood cells are made by bone marrow and released into the blood. The coagulation factor will also be tested more in-depth including factors VII and VIII assays.
On the other hand, many drugs that are in the early phase of their discovery are tested using in-vitro hepatotoxicity testing. This is the recommended method to test the compound so one can see the molecular structure of the drug. It can be tested in a controlled environment with different variables added to make structured toxicology tests. It is important that all tests be completed using a set of standards and assessments of precision and accuracy in order to have proper validation of the results.
The preclinical studies stage is the start point of conventional hematotoxicity testing. However, this type of testing is based on the elements of mature blood elements and different related parameters. There has to be more of a focus on the cells producing the elements. If the new drug to be tested had not been approved and released by the FDA, the testing that could be done is in-vitro testing. This is where the cells of the substance is tested away from a live subject and in a test tube. This type of testing is a screening system in the early phase of a drug 's development. This testing allows for a safety assessment to be made in the first stages of a drugs development and

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