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15 Cards in this Set
- Front
- Back
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what is an RER of 0.83 indicative of?
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mainly lipid oxidation
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describe the process of esterification and hydrolysis
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consume TG which is digested through lipolysis and is reesterfied in the liver for storage
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what is a chylomicron and what happens to it in the liver?
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a particles that encases TG along with phospholipids and cholesterol, converted to lipoproteins and other lipid products
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when is adipose LPL activated?
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when insulin/glucago ratio is high
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what effect does intense exercise have on FFA levels?
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lipolysis is inhibited during intense exercise as lactate increases and pH declines, and esterification of FFA is promoted
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what processes are undertaken to metabolize lipid?
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mobilization, circulation, uptake, activation, translocation, B oxidation, mitochondrial oxidation
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what LPLs are involved with mobilization, and how do they affect FFA levels?
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adipose LPL, muscle LPL and HSL LPL
adipose LPL stimulated by insulin and glucose to promote fat storage HSL LPL is stimulated by catecholamines and growth hormone to stimulate fat breakdown |
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what does uptake depend on?
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blood levels, and rate of blood flow - increase flow leads to greater uptake and utilization
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what is an SL FABP receptor site and what does it do?
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it's an SL fatty acid binding protein that works with a fatty acid transporter protein to translocate FFA across the SL
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what is involved in activation?
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raising fatty acid to a higher level and requires ATP
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what does translocation involve and what effect does malonyl CoA have on this?
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a family of CAT enzymes, each fatty acid has a specific CAT, malonyl CoA inhibits CAT enzymes in the liver and heart
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what is beta oxidation?
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cleaves two carbons from the fatty acid molecule to produce acetyl CoA which in turn produces ATP
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what regulates Beta-oxidation?
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redox potential - reduction inhibits dehydrogenases, and oxidation stimulates dehydrogenases
rate limiting enzyme is beta-ketothiolase |
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when does the glucose fatty acid cycle work?
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work during mild to moderate exercise, but mainly after glycogen depletion
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what is the crossover concept?
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balance of fat and CHO metabolism during exercise
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