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11 Cards in this Set
- Front
- Back
What is this?
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Juvenile papillomatosis (JP) is a breast tumor of young women featuring atypical papillary duct hyperplasia and numerous cysts
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What is this?
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Juvenile papillomatosis (JP) is a breast tumor of young women featuring atypical papillary duct hyperplasia and numerous cysts
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Name, prognosis and demographic?
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Benign nodules formed by the compact proliferation of tubular structures. Seen in young women.
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T/F
1. Fibroadenomas are clonal. 2. Fibroadenomas are most prevenlent post-menopausal. 3. Carry an increased risk for carcinoma. |
1. T
2. F They grow during pregnancy and with hormonal cycle but regress post menopause. 3. There is a mild increased risk. |
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Duct ectasia - Dilated large ducts with fibrous thickening of wall, elastic fibers in wall and foamy macrophages in lumen; often calcifications
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Normal breast tissue from a male breast lacks what structure compared to a female?
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Before puberty, male and female breasts consist of the same # of ducts (with myoepithelial cells) and lactiferous sinuses. During puberty in the female, development continues, reaching completion during the first pregnancy with the formation of acini from terminal aveolar buds. Acini are not present in the male breast.
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This is a breast lesion. What does it represent?
A. Infiltrating lobular carcinoma B. Sclerosing adenosis involving nerve C. Tubular carcinoma D. Ductal Carcinoma |
B. The key here is to know that benign glands in perineural spaces are reported in ~2% of cases of sclerosing adenosis.
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Name this entity.
A. Radial scar B. Microglandular adenosis C. Sclerosing adenosis D. Tubular carcinoma |
D. Tubular carcinoma. This needle biopsy shows a proliferation of tubules in and amongst benign breast tissue as well as infiltrating adipose tissue. Many of the tubules had an angulated (boat-shaped) morphology. Cytologically, these tubules lack significant atypia. A definitive diagnosis of tubular carcinoma cannot be made on needle biopsy as there may be more poorly differentiated areas that have gone unsampled. Rather, we sign these cases out as infiltrating ductal adenocarcinoma of the breast with tubular features. Microglandular adenosis is one of the few benign entities may see tubules infiltrating adipose tissue. Microglandular adenosis, however, has a classic histology composed of rounded tubules containing dense eosinophilic secretions. In microglandular adenosis the stroma shows no reaction.
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Name the entity.
A. Tubular carcinoma B. Microglandular adenosis C. Sclerosing adenosis D. Normal breast |
A. Tubular carcinoma. Tubules extend into surrounding adipose tissue. They vary from those that are round to those with an angular, pointed appearance. The connective tissue in between the tubules is somewhat myxoid in appearance. Microglandular adenosis shares with tubular carcinoma the presence of tubules within fat. However, in microglandular adenosis the tubules are perfectly round and often contain dense eosinophilic colloid secretions. Classically, microglandular adenosis lacks a prominent stromal reaction.
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Name the entity.
A. Usual ductal hyperplasia B. Florid ductal hyperplasia C. Atypical ductal hyperplasia D. Ductal carcinoma in situ |
D. Specifically, this is Micropapillary ductal carcinoma in situ. These papillae are notable for their lack of fibrovascular cores. The cells lining these dilated cystic structures and the micropapillae are pleomorphic with high nuclear-to-cytoplasmic ratios and prominent cytologic atypia.
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Name the entity.
A. Tubular carcinoma B. Microglandular adenosis C. Sclerosing adenosis D. Ductal carcinoma. |
This is microglandular adenosis. It is typified by tubules (which can be in fat) that are perfectly round and lack a myoepithelial cell layer (they are the one B9 breast epithelial lesion what breaks that rule). The tubules stain positive for S-100.
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