With new agents reported each year for occupational asthma, more than 400 agents have been recognized to cause occupational asthma (Dumas, Laurent, Bousquet, Metspalu, Milani, Kauffmann, &Moual, 2014:648). The role of repeated low-to-moderate exposure to irritants in the onset of asthma has been found to contribute to the increasing evidence, which has clinical implications as irritants should be enormously considered as potential causative agents (Dumas et al, 2014:655). As a result, there are currently no clinical diagnostic criteria that allow the acknowledgment of new-onset-asthma to low irritant exposure in each individual patient in the workplace (Tarlo, 2013: 4&5).A total of 36 agents were found to cause allergic as well as irritant
