Evaluation Of The Antidepressant Treatment Phase Essay
During the antidepressant treatment phase, we found 1) the OSA group performed significantly worse on the SRT delayed recall at week 16 compared to the non-OSA group, and the results remained significant after controlling for baseline performance, age, gender, and education; 2) the OSA group had a greater microvascular burden, including DWMHs, PVHs, and SCGs, as well as grade 2 and 3 lesions in DWM, PVH, and SCG, 3) between groups, the differences in the hippocampal and entorhinal cortex volumes were not statistically different, and the results do not change after controlling for intracranial volume.
In ANCOVA analysis, the OSA group performed significantly worse than the non-OSA group on the SRT-delayed recall (p=0.000) only after antidepressant treatment whereas the SRT immediate recalls and recognition, as well as other domains did not (See Table 2 and Figure 2). Our findings were similar to the results of a controlled study investigated memory functions in non-depressed patients with moderate to severe OSA. The two meta-analysis studies of memory functions in patients with OSA compared to age-matched norms also showed that OSA frequently affected verbal episodic memory compared to other cognitive domains, in particular, verbal delayed recall (effect sizes d= 0.44-0.52).[10, 49]
The other main finding in this study is the substantial differences in the changes of brain morphology between the OSA group and the non-OSA control group. The OSA group had…