Advantages And Disadvantages Of Oral Controlled Release Drug Delivery System

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INTRODUCTION
Oral Controlled Release Drug Delivery Systems1, 2: Oral controlled release drug delivery is a drug delivery system that provides*give the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either local or systemic action. All the pharmaceutical products formulated for systemic delivery via*throw the oral route of administration, irrespective of the mode of delivery (immediate, sustained or controlled release) and the design of dosage form (solid dispersion or liquid), must*should be developed within the intrinsic characteristics of GI physiology. Therefore
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• Posture – GRT* gastric retention time can vary*different between supine and upright ambulatory states of the patient. Concomitant drug administration – Anticholinergics *as like Atropine and Propantheline, opiates like Codeine and prokinetic agents like Metoclopramide and Cisapride.
Advantages of FDDS 25, 26:
Floating dosage systems form important technological drug delivery systems with gastric retentive behavior and offer several advantages in drug delivery. These advantages include*are:
1. Improved drug absorption, because of increased GRT* gastric retention time and more*longer time spent by the dosage form at its absorption site.
2. Controlled delivery of drugs.
3. Delivery of *the drugs for local action in the stomach.
4. Minimizing the mucosal irritation due to*caused by drugs, by drug releasing slowly at controlled rate.
5. Treatment*For cure of gastrointestinal disorders such as gastro-esophageal reflux.
6. Simple and conventional equipment for manufacture.
7. Ease of*easy to administration and better*good patient compliance.
8. The Site-specific drug delivery.
Disadvantages of

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