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13 Cards in this Set

  • Front
  • Back
Leukemoid rxn
Reactive leukocytosis
Incr WBC count w/left shift
Incr Leukocyte alkaline phosphatase
Acute lymphocytic leukemia
(a) age/presentation
(b) specific cell markers
(c) response to therapy
(d) bone marrow
(e) spread
(a) children; NOTE that t cell variety can cause a thymic mass that may compress trachea
(b) CD10
(c) good
(d) highly infiltrated by lymphoblasts
(e) CNS testes
Acute myelogenous leukemia
(a) age
(b) peripheral smear
(c) histopathologic marker
(d) significance of type M3
(a) adults mostly
(b) incr cirulcating myeloblasts on peripheral smear
(c) auer rods
(d) responds to all trans retinoic acid (vitA) inducing differentiation of myeloblasts
Chronic lymphocytic leukemia
(a) age
(b) presentation
(c) peripheral blood smear
(d) complications
(e) similar to what type of lymphoma?
(a) >60
(b) lymphadenopathy, HSM, few symptoms; generally indolent
(c) incr smudge cells in peripheral blood smear
(d) warm antibody autoimmune hemolytic anemia
(e) similar to SLL
CML
(a)age
(b) genetic defect
(c) peripheral smear/presentation
(d) treatment
(e) possible complications
(a) usually middle aged
(b) philadelphia chromosome
(c) left shift w/all stages of myeloid maturation; basophilia; splenomegaly
(d) imatinib
(e) AML (2/3) or ALL (1/3)
Hairy cell Leukemia
(a) age
(b) description of cells
(c) diagnosis
(a) elderly
(b) cMature B cells have filamentous hair like projections
(c) tartrate resistant acid phosphatase +
Adult T cell leukemia
(a) geographically concentrated where?
(b) presentation
(c) etiology
(a) japan
(b) lymphadenopathy, HSM, skin involvement, hypercalcemia
(c) HTLV-1; exposure to virus may be decades earlier
Auer rods
Peroxidase positive cytoplasmic inclusions in granulocytes and myeloblasts
Seen commonly in AML (M3)
What is a possible consequence of treatment of AML M3?
Release of auer rods leading to DIC
Langerhan's cell histiocytosis
Proliferative disorders of langerhans (dendritic) cells from monocyte lineage
Markers in histiocytosis X
S-100 and CD1a
EM signs of histiocytosis X
Birbeck granules (tennis rackets) are characteristic
Older terms for histiocytsosis X
Letter Siwe Disease
Hand Schuller Christian disease
Eosinophilic granulomas