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13 Cards in this Set
- Front
- Back
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Leukemoid rxn
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Reactive leukocytosis
Incr WBC count w/left shift Incr Leukocyte alkaline phosphatase |
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Acute lymphocytic leukemia
(a) age/presentation (b) specific cell markers (c) response to therapy (d) bone marrow (e) spread |
(a) children; NOTE that t cell variety can cause a thymic mass that may compress trachea
(b) CD10 (c) good (d) highly infiltrated by lymphoblasts (e) CNS testes |
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Acute myelogenous leukemia
(a) age (b) peripheral smear (c) histopathologic marker (d) significance of type M3 |
(a) adults mostly
(b) incr cirulcating myeloblasts on peripheral smear (c) auer rods (d) responds to all trans retinoic acid (vitA) inducing differentiation of myeloblasts |
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Chronic lymphocytic leukemia
(a) age (b) presentation (c) peripheral blood smear (d) complications (e) similar to what type of lymphoma? |
(a) >60
(b) lymphadenopathy, HSM, few symptoms; generally indolent (c) incr smudge cells in peripheral blood smear (d) warm antibody autoimmune hemolytic anemia (e) similar to SLL |
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CML
(a)age (b) genetic defect (c) peripheral smear/presentation (d) treatment (e) possible complications |
(a) usually middle aged
(b) philadelphia chromosome (c) left shift w/all stages of myeloid maturation; basophilia; splenomegaly (d) imatinib (e) AML (2/3) or ALL (1/3) |
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Hairy cell Leukemia
(a) age (b) description of cells (c) diagnosis |
(a) elderly
(b) cMature B cells have filamentous hair like projections (c) tartrate resistant acid phosphatase + |
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Adult T cell leukemia
(a) geographically concentrated where? (b) presentation (c) etiology |
(a) japan
(b) lymphadenopathy, HSM, skin involvement, hypercalcemia (c) HTLV-1; exposure to virus may be decades earlier |
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Auer rods
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Peroxidase positive cytoplasmic inclusions in granulocytes and myeloblasts
Seen commonly in AML (M3) |
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What is a possible consequence of treatment of AML M3?
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Release of auer rods leading to DIC
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Langerhan's cell histiocytosis
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Proliferative disorders of langerhans (dendritic) cells from monocyte lineage
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Markers in histiocytosis X
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S-100 and CD1a
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EM signs of histiocytosis X
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Birbeck granules (tennis rackets) are characteristic
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Older terms for histiocytsosis X
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Letter Siwe Disease
Hand Schuller Christian disease Eosinophilic granulomas |
