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28 Cards in this Set

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Reid Sternberg cells (cell markers)
Tumor giant cells distinctive for hodgkin's lymphoma
Binucleate or bilobed
CD30+ and CD15+
B cell origin
Nonspecific lymphadenitis
(a) presentation
(b) cause
(a) enlarged, tender LN following
(b) drugs, toxins, infection
Causes of monocytosis
TB
Endocarditis
Malaria
Brucellosis
Rickettsiosis
Lymphocytosis causes
TB
Brucellosis
Pertussis
Viral hepatitis
CMV
Infectious mono
Eosinophilic leukocytosis causes
Neoplasms
Allergy
Asthma
Collagen vascular diseases
Parasitic infection
Skin rashes
Follicular hyperplasia
(a) describe
(b) cause
(c) etiologies
(a) large germinal centers, containing mostly B cells, helper T cells, histiocytes
(b) B cell antibody response
(c) bacterial infection, exposure to new antigen
Paracortical hyperplasia
(a) describe
(b) cause
(c) etiologies
(a) reactive changes
(b) T cell rxn
(c) seen w/phenytoin use, viral infections, or secondary immune response
Sinus histiocytosis
(a) describe
(b) cause
Lymphatic sinusoids prominent and distended w/macs
Seen in nodes draining carcinoma or any chronic inflammation
4 types of hodgkin's lymphoma
Nodular sclerosing
Mixed cellularity
Lymphocyte predominant
Lymphocyte depleted
Nodular sclerosing hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments
(a) RS cells: +
(b) lymphocyte: +++
(c) prognosis: excellent
(d) comments: collagen banding; F>M; primarily young adults
Mixed cellularity hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments
(a) RS cells: ++++
(b) lymphocyte: +++
(c) prognosis: intermediate
(d) comments: lots of RS cells
Lymphocyte predominant hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments
(a) RS cells: +
(b) lymphocyte: ++++
(c) prognosis: excellent
(d) comments: <25YO M
Lymphocyte depleted hodgkin's lymphoma
(a) RS cells
(b) lymphocyte
(c) prognosis
(d) comments
(a) RS cells: RS high relative to lymphocytes
(b) lymphocyte: +
(c) prognosis: poor
(d) comments: older males with disseminated disease
Most important factor in prognosis for hodgkins lymphoma
Stage
Small lymphocytic lymphoma (NHL)
(a) age
(b) cell type
(c) genetics
(d) presentation
(a) age: adults
(b) cell type: B cells
(c) genetics: n/a
(d) presentation: like CLL w/focal mass; low grade
Follicular lymphoma (small cleaved cell)
(a) age
(b) cell type
(c) genetics
(d) presentation
(a) age: adults
(b) cell type: B cells
(c) genetics: t(14;18) bcl-2
(d) presentation: difficult to cure; indolent course
Diffuse large cell lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation
(a) age: usually older adults; 20% in children
(b) cell type: 80% B, 20% T (mature)
(c) genetics: n/a
(d) presentation: aggressive, but many are curable
Mantle cell lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation
(a) age: adults
(b) cell type: B cells
(c) genetics: t(11;14)
(d) presentation: poor prognosis, CD5+
Lymphoblastic lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation
(a) age: usually children
(b) cell type: immature T cells
(c) genetics: n/a
(d) presentation: mediastinal mass common
Burkitt's lymphoma
(a) age
(b) cell type
(c) genetics
(d) presentation
(a) age: mostly children
(b) cell type: B cell
(c) genetics: t (8; 14) c myc
(d) presentation: "starry sky" (lymphocytes w/interspersed macs); assoc w/EBV; jaw lesion common in endemic; pelvis or GI common in sporadic
Translocation in CML
t(9;22) BCR-ABL (philadelphia chromosome)
Translocation in Burkitt's lymphoma
t(8;14) c-myc activation
Translocation in Follicular lymphoma
t(14;18) bcl-2 activation
Translocation in M3 type AML
t(15;17)
Translocation in Ewing's sarcoma
t(11;22)
Translocation in mantle cell lymphoma
t(11;14)
Mycosis fungoides
(a) presentation
(b) cell type
(a) skin lymphoma; inflammation, plaque, tumor can occur
(b) neoplastic T cell infiltrates in the dermis
Sezary syndrome
(a) presentation
(b) cell type
(a) pruritic erythroderma, exfoliation, lymphadenopathy
(b) "sezary cells" T cells with cerebriform nuclei (same as mycosis fungoides)