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9 Cards in this Set

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Adult renal derivative of the following:
(1) Pronephros
(2) mesonephros
(3) metanephros
(4) urogenital sinus
(5) ureteric bud
(1) Pronephros: not functional and completely degenerates
(2) mesonephros: interim kidney for 1st tri; degenerates except for mesonephric (wolfian) ducts in males
(3) metanephros: permanent kidney (glomerulus to distal convoluted tubule)
(4) urogenital sinus: deveops into bladder, urethra, allantois
(5) ureteric bud: Outgrowth of mesonephric duct which gives rise to collecting duct, calyces, pelvis, ureter
Describe potter's syndrome
Bilateral renal agenesis leads to oligohydramnios with sequellae of limb/facial deformities, and pulmonary hypoplasia. Caused by malformation of ureteric bud.
Describe horseshoe kidney
Inferior poles of both kidneys fuse and are trapped under inferior mesenteric artery but kidney fct is normal.
Adult derivatives of mesonephric duct (wollfian)
Seminal vesicles, Epidiymis, Ejaculatory duct, Ductus deferens
Derivatives of Paramesonephric ducts (mullerian)
Fallopian tube, uterus, and upper 1/3 of vagina
Describe induction of male sex
SRY gene on y chromosome codes for testis-determining factor. MIH secreted by sertoli cells of testes which suppresses paramesonephric ducts. Increased androgens (Leydig cells) cause development of mesonephric ducts.
Male derivatives of the following embronic structures:
(1) Genital tubercle
(2) urogenital sinus
(3) urogenital folds
(4) labioscrotal swellings
(1) glans penis, corpus spongiosum
(2) bulbourethral glands, prostate
(3) ventral shaft of penis (penile urethra)
(4) scrotum
Female derivatives of the following embronic structures:
(1) Genital tubercle
(2) urogenital sinus
(3) urogenital folds
(4) labioscrotal swellings
(1) glans clitoris, vestibular bulb
(2) greater vestibular glands (of bartholin), urethral and paraurethral Glands (of Skene)
(3) labia minora
(4) labia majora
Cause and associations of
(1) hypospadias
(2) epispadius
(1) Abnormal opening of penile urethra on inferior/ventral side of penis due to failure of urethral folds to close. Fix to prevent UTI
(2) Abnormal opening of penile urethra on superior/dorsal side of penis due to faulty positioning of genital tubercle. Associated with exstrophy of bladder.