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10 Cards in this Set

  • Front
  • Back
Define seronegative spondyloarthropathies (genetic associations and epidemiology)
Name the 3 diseases in this category
Arthritis without RF
Strong association with HLA B27 (codes for MHC I)
Occurs more in males
Anklyosing spondylitis, Reiter's syndrome, Psoriatic arthritis
Signs/symptoms of ankylosing spondylitis
Chronic inflammatory disease of spine and sacryoiliac joints; stiff spine due to fusion of joints; uveitis and aortic regurgitation seen; bamboo spine on x ray
Associations of anklyosing spondylitis
Inflammatory bowel disease
Classic triad of Reiter's syndrome
(1) conjunctivitis and anterior uveitis
(2) urethritis
(3) arthritis
Possible causative agent to Reiter's?
Chlamydia
Psoriatic arthritis presentation
Joint pain and stiffness associated w/psoriasis; asymmetric and patchy involvement
X ray signs of psoriatic arthritis
Dactylitis (sausage fingers)
"pencil in a cup"
Why do SLE patients have false positives on RPR/VDRL syphilis tests?
Antiphospholipid antibodies cross react w/cardiolipin used in tests
Autoantibodies in SLE and their significance
(1) ANA (sensitive, not specific)
(2) anti dsDNA (very secific, poor prognosis)
(3) anti-Smith (very specific but not prognostic)
(4) antiHistone (drug induced lupus)
Systemic lupus presentation
I'M DAMN SHARP
Ig's (anti dsDNA, anti-Sm, andphospholipid)
Malar rash
Discoid rash
ANA
Mucositis (oropharyngeal ulcers)
Neurological disorders
Serositis (pleuritis, pericarditis)
Hematologic disorders
Arthritis
Renal disorders
Photosensitivity