Neuroscience Physiology

Front 1

What is the difference between a receptor potential and a generator potential?

Back 1

receptor potential is the potential from the sensory receptor and a generator potential is the potential from a sensory neuron

Front 2

What neuron type are all the sensory receptors?

Back 2

A β

Front 3

What receptor is closest to skin surface?

Back 3

Meissners in dermal papillae </img>

Front 4

Which receptor is deepest in?

Back 4

Pacinian corpuscle in dermis

Front 5

Which receptors are rapidly adapting?

Back 5

Merkels and Pacinian

Front 6

Which receptors are slowly adapting?

Back 6

Meissners and Ruffini

Front 7

What has the smallest receptive field?

Back 7

Merkels

Front 8

What has the largest receptive field?

Back 8

Ruffini

Front 9

What has the largest two point discriination?

Back 9

pacinian

Front 10

Which has the smallest two point discrimination

Back 10

Merkels

Front 11

What is the effective stimuli for meissner's corpuscles?

Back 11

Skin motion

Front 12

What is the effective stimuli for Merkel's corpuscles?

Back 12

Edges
Points
Corners
Curvature

Front 13

What is the effective stimuli for Ruffini corpuscles?

Back 13

skin stretch

Front 14

What is the effective stimuli for Pacinian corpuscles?

Back 14

vibration

Front 15

What is the function of the Meissner's corpuscles?

Back 15

motion detection and grip control so it would make sense that it is slow adapting with a relatively small receptor field and two point discrimination and ts slow adapting because its only really there for motion detection

Front 16

What is the purpose of Merkel's Corpuscles?

Back 16

fine form and texture perception which would make since since it is the smallest receptor field, rapidly adapting and smallest two point discrimination

Front 17

What is the purpose of Ruffini corpuscles?

Back 17

tangential force, hand shape and motion detection which would make since since its slow adapting and has the largest receptive field and the next to largest two point discrimination

Front 18

What is the purpose of Pacinian corpuscles?

Back 18

Distant events transmitted through vibrations which would make sense because its rapidly adapting (it has to be to detect such distant events), its effective stimuli is vibration and it has the next to largest receptor field size

Front 19

What are the joint capsules/Ruffini endings sensing?

Back 19

limb position

Front 20

What type of sensory fibers are in the joint capsule?

Back 20

A &beta; or II

Front 21

What is the golgi tendon organ sensing?

Back 21

limb position

Front 22

What type of fibers are in the golgi tendon organ?

Back 22

A &alpha;/ Ib

Front 23

What do the muscle spindles sense?

Back 23

limb movement (Dynamic) and limb position (static)

Front 24

What is the sensory fiber associated with the muscle spindles?

Back 24

A&alpha;/Ia (primary)
A&Beta; II (Secondary)

Front 25

What sensory afferent fibers are associated with muscle spindles?

Back 25

Ia

Front 26

What are the characteristics of Ia fibers?

Back 26

largest and fastest and myelinated

Front 27

What fibers are associated with touch?

Back 27

Ia and II and A &beta;

Front 28

What are the characteristics of those fibers

Back 28

myelinated and fast but not fastest, relatively large

Front 29

What are the fibers associated with pain and temperature?

Back 29

A&beta; and A&delta/C;

Front 30

What is the difference between A&beta; and A&delta;

Back 30

A&beta; is myelinated and A&delta;/C fibers are not myelinated.

Front 31

What are the 7 symptoms associated with lesion in the dorsal column?

Back 31

1) loss of two point discrimination
2) loss of vibration sense
3) inability to recognize limb position without visual information
4) agraphesthesia
5) astereognosis
6) Positive romberg sign

Front 32

What type of fibers are both mechanosensitive nociceptive receptors and mechanotermal receptors?

Back 32

A&delta;

Front 33

What type of fiber is the polymodal nociceptor?

Back 33

C fiber

Front 34

Do A&delta; and C fibers give a different pain response?

Back 34

A&/IIIdelta; fibers are for fast pain
C/IV fibers are for slow pain

Front 35

What are the characteristics of fast pain/first pain/epicritic pain? 3 characteristics and an example

Back 35

1) rapid
2) sharp/pricking/acute/electric
3) well localized
4) knife/needle stick

Front 36

What are the 3 characteristics of slow pain/second pain/protopathic pain and an example?

Back 36

1) delayed for more than a second after injury
2) slow, burning, aching, throbbing, nauseous, chornic
3) diffuse
4)crush injury/burn

Front 37

What horn are we looking into when we have the layers ?

Back 37

the dorsal horn between the dorsal root ganglion and decussation

Front 38

Which layer is closest to the DRG? which layer is closest to the decussation?

Back 38

layer 1 is closest to DRG
layer 5 is closest to decussation

Front 39

Where are A&delta; fibers in the dorsal horn?

Back 39

layer I and layer IV for nocireceptor and polymodal neurons

Front 40

Where are C layers in the dorsal horn?

Back 40

layer I and layer II

Front 41

What is in the layer 1?

Back 41

nociceptor specific

Front 42

What is in layer II?

Back 42

substantia gelatinosa/inhibitory interneurons

Front 43

What is in layer V?

Back 43

wide dynamic range/polymodal sensory neurons

Front 44

What is the general TRP receptor class?

Back 44

respond to capsacin and heat and are voltage gated Na and Ca channels

Front 45

What is the TRP V receptor? What fibers is it found in?

Back 45

A&delta; and C fibers and is for uncomfortable temperature and spicy food

Front 46

What is the TRP V2 receptor for? What fibers is it located in?

Back 46

A&delta;
temperature greater than 50 degrees and not sensitive to spicy food

Front 47

What are the C layer I and V fibers doing?

Back 47

activate pain projection neruons and inhibit SG cells

Front 48

What are the A&beta; fibers doing?

Back 48

stimulate SG cells
inhibit pain projection neurons
decrease pain transmission
these are also the neurons that do fine discrimination and touch