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13 Cards in this Set
- Front
- Back
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What are glucocorticoid analouges |
Molecules we have synthesised that are similarwhat to glucocorticoids our body makes |
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What makes glucocorticoids |
Cholesterol |
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What are glucocorticoids |
Potently anti inflammatory |
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Whats an example of a glucocorticoids humans make |
Cortisol |
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Whats a powerful glucocorticoids |
Dexamethasone |
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Explain the usual pathway for inflammation |
Stimulus- cytokines- then through cox to PGS and PGES |
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Name some of the cytokines thats produced |
TNF, IL-1,IL-2, IFN-y |
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What do PGs and PGEs give you |
Pain, swelling |
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What do steroids supress and how do they do it |
Cytokines-switch off directly, switch gene of COX- not direct switch off to COX, it upregulates the production of lipocortin which inhibits the generation of arachadonic acid |
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Through the steroid inhibition of inflammation what can an effect be |
Start to remodel and person and shape of their body and face called moon face |
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What is the relative anti inflammatory potency idf cortisol, betamethasone and dexamethasone |
Cortisol-1, 25, 25 25 is most potent we have ever seen |
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What is a steroids mechanism |
Steroid moves into cell and binds to receptor thats masked by HSP 90. Once steroid bunds to receptor it disengages the protein and is free to move into nucleus In nucleus it can bind to particularly regulatory genes |
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When the steroid moves into nucleus what can happen |
Transrepression-binds to dna in the same site where another transcription factor would bind preventing the transcription of genes that are transcribed by that factor Transactivation- result in the regulation of gene expression i.e anti inflammatory proteins |
