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13 Cards in this Set
- Front
- Back
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How to t cell goes on to divide |
T cells divide after antigen is presehted 1 T cell thats specific to the antigen thats presented will go through clonal expansion Even if you dont have CD28(costimulatory) you can still get activation just not 100% |
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What do mitogens do in T cell activation pathway |
ConA or PHA are lectins (proteins that have high affinity for binding to sugars |
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Release of IL-2 causes what |
T cell proliferation |
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What does Ca ionophore do |
A hole that only calcium fits through, they punch a hole in the membrane to allow calcium to flood in stimulates a calcium signal |
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What does csa block |
Even after calcium comes in means it blocks a step after calcium |
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Whats the observations of CsA and fk506 |
Affect Ca 2+ pathways Inhibit ca2+ ionophores Do not affect generation of ca2+( doesnt stop it from being made just stops it from acting downstream) Fk506 and Csa affect pathway after Ca2+ |
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Where does CsA or FK506 bind |
Cyclosporin is highly lipid soluble Synthesised cyclosporin doesn’t bind to cells surface it hinds to a protein within the cytosol |
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What is cyclosporin As binding protein |
Cyclophillin |
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What is FK506 binding protein |
FKBP |
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What is rapamycins binding protein |
FKBP |
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What are cyclophillin and FKBP Said to be |
Peptidyl-prolyl isomerasesn(PPI) |
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What are ppis and rotamases |
They are there to speed up the folding of proteins that are newly synthesised Rotamases-rotate the proteins |
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What inhibits rotamases and what does this suggest |
Csa fk506 and rapamycin all inhibit rotamase Antagonists also inhibit rotamase activity and antagonists are not immunosuppressive so this implies that rotamase activity isn’t involved in suppression |
