Know One Drug Erin Wu I chose losartan. For your molecule: Note the primary indication, and a secondary indication (even if off label) The primary indication is hypertension. It is also used for diabetic neuropathy and hypertension with left ventricular hypertrophy.…
Why is this drug used? Lisinopril is used to treat heart failure, high blood pressure, and to assist in the survival in patients who may have had a heart attack. It is in a class of drugs called Angiotensin Converting Enzyme blockers (ACE). This drug works by reducing certain chemicals that squeeze the blood vessels, so that the blood can flow smoother and the heart can pump the blood better.…
1. The 48 years old Native American women presenting to the Indian Hospital is taking Lisinopril because of hypertension as one of the conditions documented in her past medical history. Hypertension is supported by the current measurements of the blood pressure readings of 165/100. Lisinopril is an angiotensin –converting enzyme inhibitor (ACE) considered as one of the first line treatment option for hypertension. The pharmacological mechanism of action for Lisinopril is to inhibit the action of angiotensin- converting enzyme by preventing conversion of angiotensin I to angiotensin II which will result in decreased vasoconstriction of the vessels and water reabsorption.…
Michelle DeSanti Biology 22 (24556) Professor Linder 4 May 2017 Clinical outcomes: Evolocumab use for Cardiovascular Disease High cholesterol, two words that can certainly ignite a fear in a patient who is newly diagnosed with this common issue. Which brings us to the question, what exactly is high cholesterol and what makes it so bad? Low-density lipoprotein cholesterol, also known as LDL cholesterol is what many consider to be the “bad cholesterol”.…
If it is postulated that the muscle responds to the tension in the vessel wall, this theory…
1. Amlodipine is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as long acting dihydropyridine-type calcium channel blockers. Amlodipine widen the blood vessels and improves blood flow. Widening of these blood vessels lowers blood pressure.…
1. An aura is typically a short period of sensory disturbance (e.g. a bright light) which signals that ___________ will soon occur. a. Migraine episode b. Seizure episode c. Hallucination episode d. All of the above e. A and B only 2. ____________ is the human form of mad cow disease which is caused by the consumption of contaminated beef from cattle.…
Introduction: Heart Failure (HF) is a complex clinical syndrome that affects the structural and functional capacity of the ventricle to load or expel blood. According to Ferri (2016, p. 576), the principal symptoms of HF are dyspnea and fatigue which can significantly reduce an individual's exercise tolerance. Due to the various signs and symptoms associated with HF, multiple pharmacotherapies including ACE inhibitors, beta-blockers, calcium channel inotropic agents, and diuretics has been utilized to alleviate HF manifestations and prolong the person's life expectancy. In this discussion topic, I will be summarizing a particular class of diuretics that plays a significant role in alleviating the effort the heart has to expend.…
When this sodium reaches the terminal buttons, calcium enters the cell and causing vesicles to bind to the cell wall and release the content that is present, usually a neurotransmitter. This neurotransmitter will now go to a different neuron, and incite an action potential. This whole process occurs all the time will billions of neurons. It is an exceedingly complex system that is vital for the survival of species. What if the sodium channels were blocked when there is an impulse or stimulus present.…
vomiting. Since the stomach relies on a uniform muscle movement in order to digest food (peristalsis), introducing a toxin that disrupts normal muscle movement will cause the cramping and pain sensation in a person’s gastrointestinal tract. Although this toxin is interfering with neuromuscular signaling, all of the pain signaling pathways are still fully functional since they work with a different set of neurotransmitters and pathways. Inhibition of the neuromuscular junction does not always negatively affect an organism. Some drugs used today purposely inhibit neuromuscular junction functions.…
Proton pump inhibitors are a group of drugs whose chief action is a pronounced and long lasting reduction of gastric acid reduction. They are the greatest potent inhibitors of acid secretion available. Proton pump inhibitors are amid the most widely sold drugs in the world. They are used to treat many conditions such as dyspepsia, peptic ulcer, gastroesophageal reflux disease, Zollinger-Ellison syndrome. Anti-ulcer drugs are drugs used to treat stomach ulcers and the upper part of the small intestine.…
Capital Punishment In California Capital Punishment in California has carried out seven hundred and nine executions from seventeen seventy eight to nineteen seventy two. In nineteen seventy two, the California Supreme Court in the decision of the People V. Anderson, found that the death penalty violates the state constitution. A few months later, California voters reinstated the death penalty with Proposition seventeen, legalizing the death penalty. Since then there have been thirteen executions, the last one in two thousand and six.…
Congestive Heart Failure or CHF is a disease that makes it hard for the body to pump enough oxygen-rich blood to the body's organs. The heart muscle becomes damaged from other conditions such as myocardial ischemia, hypertension and arrhythmia. When this happens the heart is very weak, but it works too hard to efficiently pump enough oxygen-rich blood to the body resulting in life-threatening congestion. Congestive heart failure can affect all ages, from children to the elderly. Almost five million Americans currently live with CHF and there are 550,000 new cases each year.…
Assignment -1 Serotonin syndrome: • Definition. • Causes. • Risk factors • Symptoms. • Diagnosis.…
RESULTS AND DISCUSSION The drug release study of Propranolol from the synthesized prodrugs9a and 9c proved that they hydrolyze significantly at pH 6.8 & 7.4. This proves the stability of prodrug at gastric pH and easily gets hydrolyzed at both blood and intestinal pH, and would be available for the action by significantly eliminating the problem of fast metabolism and local irritation when compared to the parent drug. The % CDR of 9c at pH 7.4 was found to be maximum i.e. 92% within 3 hrs and at pH 6.8 it is 86% but at pH 1.2 it is only 8.13%, whereas in case of 9a the % drug release is 83% at pH 7.4 and 71% in pH 6.8 but at pH 1.2 it is only 10.6%. The maximum drug release from the synthesized prodrugs was found at slightly alkaline pH, due…