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15 Cards in this Set
- Front
- Back
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Name another example of specific immunosuppression |
Macrolides- fungal derivatives Less damaging side effects |
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What are some anti rejection drugs |
Main is cylosporin A then discovered FK-506, then rapamycin |
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Why are these antirejection drugs called agonists |
They actively shut down immune responses |
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What is a bit of history of cyclosporin |
Pharmaceutics discoverer the immunosuppressant agent that ultimately moved transplantation from the realm of curiosity into routine therapy |
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1 year kidney survival pre CsA |
50% cadaver (someone dies and donates their organs) 75% living donor (related) |
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1 year kidney survival after csa and dose given |
85% cadaver 95% living donor (related) 20mg/kg- some toxicity/nephrotoxicity major(99% of toxicity is nephrotoxicity) |
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Cyclosporin A is potent suppression of what |
Alloantigen specific T cell numbers T-cell proliferation Cytotoxic T cell numbers Il-2 and ifn-γ |
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What is Il-2 |
Primary T cell growth factor Use this as a marker at T cell proliferation |
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What does cytosporin do to cells |
Does not kill the cells |
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FK-506 liver and liver/intestine transplant success rate |
100% |
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Dose you would use for FK-506 |
150 μg/kg 100 x more potent that csa Side effects nephrotoxicity but far less that csa so very selective |
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Dose used for cyclosporin |
20mg/kg |
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Why do you get less toxicity with FK506 |
Give people less compound as its potent More compound you give someone the more unselective effects happen If you only give someone a little but it will only go to selective places- cyclosporin is more commonly used but FK-506 is more expensive |
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Characteristics in rapamycin |
Effective even after T cell activation especially in highly histoincompatible organs (heart) Greater potency and graft survival time than FK506 |
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No major renal toxicity but: |
In experimental animals Gi ulceration Vasculitis Testicular atrophy |
