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185 Cards in this Set
- Front
- Back
- 3rd side (hint)
Skin Facts
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- 7% of our body weight comes from skin
- 1.8 square meters of surface area - Skin is an organ |
-What % of body weight comes from skin?
- How many square meters of surface area? -Skin is an ________. |
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Skin Functions
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- Physical protection from UV light, microorganisms, and water.
- Hydroregulation - Thermoregulation - Absorption and synthesis - Sensory reception - Communication |
6 functions
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Layers of the Skin
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- Epidermis (thin outer layer)
- Dermis (thicker inner layer of fibrous connective tissues) -Hypodermis (not truly skin) |
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Epidermis layers
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1. Stratum corneum (dead, outer layer)
2. Stratum lucidum (dead, thin clear layer on the lips and palms and soles of feet) 3. Stratum granulosum (alive, 3-5 rows) 4. Stratum spinosum (alive, 8-12 layers) 5. Stratum basale (alive, 1 layer) |
-Layers
-Dead/alive -Location or how many rows |
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Skin coloration
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- Melanin (brown)
- Carotene (yellow) - Hemoglobin (red/pink) (Cyanosis is a lack of oxygen, where a person looks blueish) |
- 3 types
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Dermis Layers
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- Papillary layer (Top 20%)
- Reticular layer |
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Tactile Sensors of Dermis
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- Free nerve endings: Touch (light)
- Meissner's Corpuscles: Touch (light) - Pacinian Corpuscles: Deep pressure |
- 3 sensors
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Nail Facts
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- Functions: protect fingers & toes, help pick up small objects
- Compressed (keratinized) layer of stratum corneum - 1 mm/week growth |
- Functions
- fact - How much growth per week? |
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Hair Facts
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- No real purpose
- Hard keratin - 2 mm/week growth - Fastest growth till 40 years old |
- 4 facts
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Glands
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- Sweat (sudoriferous): coiled tubular
- Sebaceous: Sebum - Ceruminous: wax - Mammary: lactation |
- 4 glands/ stuff they secrete
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Burns
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- 1st degree: Epidermis damaged (sunburn)
- 2nd degree: Epidermis and dermis damaged (complete recovery - 3rd degree: Epidermis and dermis destroyed (skin grafts) |
-Degrees
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The Rule of Nines
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- Estimates extent of burns
- Anterior & Posterior head & neck: 9% - Anterior & Posterior upper limbs: 18% - Anterior & Posterior trunk: 36% - Perineum: 1% - Anterior & Posterior Lower Limbs: 36% |
- Burn percentages
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Skin Cancer ABCDs
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- Assymetry
- Border irregularity - Color - Diameter - Elevation |
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Effects of Aging on Skin
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- Thinner, fat loss from hypodermis
- Drier, sweat and sebaceous glands - Less elastic, collagen thickens and stiffens |
- 3 effects
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Osteology
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The study of bone and bone tissue
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Arthology
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Study of joints and articulations
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Functions of Skeletal System
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1) Support: Rigid framework for softer tissues and organs
2) Protection: Brain and spinal cord, organs 3) Body movement: Anchor site for muscles, levers 4) Mineral storage: Calcium, phosphorus 5) Hemopoesis: Blood formation |
- 5 functions
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Axial Skeleton
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- Skull (auditory ossicles)
- Hyoid - Spine - Rib cage - 80 bones |
- Parts
- How many total bones |
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Appendicular Skeleton
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- Pectoral girdle
- Arms - Pelvic girdle - Legs - 126 bones |
- Parts
- How many total bones |
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Bone Classifications
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- Long Bone (Metatarsals, metacarpals, humerus, radius, ulna, tibia, fibula, femur. All have an elongated axis)
- Short Bone (Talus, carpal, tarsal, tend to be in wrist. Chunks, no axis) - Flat (ribs, ilium. Clavicle, sternum, skull) - Irregular (everything else, vertebra, sacrum, ishium) |
- 4 types and examples
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Bone Cells
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- Osteogenic: Immature bone cell in periosteum and endosteum, responds to injury (osteoblasts and osteoclasts)
- Osteoblasts: Form bone and will become osteocytes - Osteocytes: Mature bone cells - Osteoclasts: Reabsorber of bone tissue - Bone lining: Cover bone and regulate mineral movement into and out of bone |
- 5 types
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Spongy bone
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- Trabeculae is in place to resist bending
- Shock absorbing - Present in the ends of long bones |
- 3 facts
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Wolff's Law
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Bones respond to the stresses that we place on them. Can make bones bigger and stronger by exercising. If you can't move due to an injury, bones will begin to atrophy.
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Osteoporosis
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- Weakening of bone
- Bones get bigger and thicker, but quality goes down. - Decrease in bone mineral density and increase in porosity |
- 3 facts
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Fractures
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- Comminuted: Broken to pieces but still inside
- Compression: Crack or smash due to squeeze - Depressed: Bone gets pushed into tissue underneath - Epiphyseal: Goes through the growth plate - Greenstick: Partial break, like as if bent back and forth - Spiral: Twisting fracture, on an oblique plane |
- 6 types
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Fracture Healing
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- Bone has a good blood supply
- When it first breaks, it bleeds and forms a blood clot (Hematoma) - Callus forms around clot (fibrocartilaginous) - Bony callus forms - Bone remodeling occurs |
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Sphenoid
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- Most commonly fractured bone in skull, because it is thin walled and delicate
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Mandible
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- Biggest and strongest bone in the face. Getting hit in the chin is a good way to get a concussion.
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Hyoid
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- It is the only bone in the body that doesn't touch another bone
- If it is broken, the person was strangled |
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Cervical Curvature
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- Concave
- C1-C7 - Secondary - Lordotic |
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Thoracic Curvature
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- Convex
- T1-T12 - Primary - Kyphotic |
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Lumbar Curvature
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-Concave
- L1-L5 - Secondary - Lordotic |
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Sacral Curvature
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- Convex
- 5 fused vertebrae sacrum - (Pelvic is primary and kyphotic) |
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Clavicle
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Most often fractured bone in the trunk
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Femur
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Biggest and strongest bone in the body
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Joints
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Where 2 or more bones come together, doesn't need to move.
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Fibrous Joints
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- No joint cavity, strong fibrous connective bonds. In general, bones don't move
- Sutures: Connective tissue is bone; Immovable; only in skull - Syndesmoses: Linked by interosseous ligaments; distal radio/ulnar; distal tibia/fibula - Gomphoses: tooth socket; periodontal ligament; congruent joint, because socket and tooth match up |
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Cartilagenous Joints
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- No joint cavity, cartilage type bonds; Slightly movable
- Synchondroses: Hyaline cartilage between bones; between ribs & sternum, growth plates, between diaphyses & epiphyses - Sympheses: fibrocartilage between bones; symphysis pubis, intervertebral joints |
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Synovial Joints
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- Joint cavity, synovial membrane/fluid
- freely movable |
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Structure of Synovial Joints
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- Articular Cartilage: Hyaline cartilage on the ends of bones
- Synovial cavity: filled with fluid - Articular capsule: fibrous capsule, synovial membrane - Synovial fluid: viscous lubricating fluid - Reinforcing ligaments: Capsular, extracapsular, intracapsular - Nerves & vessels: Pain & proprioception |
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Plane (gliding) Joint
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- Nonaxial, slip/slide activity
- Flat (nearly) articulating surfaces - Intercarpal joint, intertarsal joint |
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Hinge Joint
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- Uniaxial (movement in 1 plane)
- One surface convex and the other concave - Strong collateral ligaments - Elbow, interphalangeal, knee |
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Pivot Joint
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- Uniaxial (bone rotates around itself or another bone)
- One surface rounded and one has a depression - Articulation between axis and atlas, proximal radioulnar joint |
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Condyloid Joint
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- Biaxial (up/down side/side)
- 1 concave and 1 convex surface - Metacarpophalangeal joints of fingers (MCP1 is hinge) |
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Saddle Joint
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- Biaxial (up/down side/side)
- 1 concave and 1 convex - Carpometacarpal joint I, Sternoclavicular |
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Ball-and-Socket Joint
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- Triaxial (movement in all directions)
- Articulation of rounded convex surface and cuplike cavity - Hip & shoulder are examples |
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Factors influencing joint stability
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- Passive: shapes of articulating surface; ligaments; more congruent bones more stable
- Active: muscle tone; muscles can contract to stabilize joints |
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Temporomandibular Joint
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- Bones: Temporal and mandible
- Hinge & sliding - Articular disc - Most easily dislocated joint in the body - TMJ syndrome - Has a meniscus, like the knee |
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Sternoclavicular Joint
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- Bones: Sternum and clavicle
- Saddle - Articular disc - Has meniscus - Critical joint (only bony attachment of the upper extremity - Most frequently dislocated joint of the rib cage (still not very frequently dislocated) |
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Acromioclavicular Joint
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- Bones: Acromion process of scapula & clavicle
- Gliding - Shoulder separation (Grade 1, stretching of acromioclavicular ligament; Grade 2, Torn acromioclavicular, stretched coricoclavicular; Grade 3, completely torn acromioclavicular and coricoclavicular ligaments |
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Glenohumeral Joint
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- Most complicated joint in the body
- Bones: humerus & glenoid fossa - Ball & socket - Stability (SITS, Supraspinatus, Intraspinatus, etc) - Kind of like golf ball and tee, not much keeping it there - Vulnerable position is abduction and external rotation |
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Hip Joint
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- Ball and socket
- Joint capsule (Iliofemoral, Pubofemoral, and Ischiofemoral ligaments) |
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Knee Joint
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- Modified hinge
- Stability (Ligaments & cartilage, ACL, PCL, LCL, MCL) |
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Ankle Joint
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- Hinge
- Stability (Medial: deltoid ligament; Lateral: anterior talofibular, calcaneofibular, posterior talofibular - Most sprains happen laterally |
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Osteoarthritis
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- Cartilage degeneration
- Not caused by knuckle cracking |
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Muscular Tissue
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- Only contractile tissue
- Over 600 skeletal muscles - About 50% of body weight - Functions: movement, maintenance of posture, joint stabilization |
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Special Features of Muscles
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- Contractability (ability to shorten)
- Excitability/irritability (sensitive to nerve impulses) - Extensibility (when relaxed, muscles can stretch) - Elasticity (After stretching can return to regular length) - |
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Skeletal Muscle
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- Muscle fiber = muscle cell
- Endomysium: connective tissue that surrounds a muscle cell - Fascicle: bundle of muscle cells - Perimysium: connective tissue around each bundle (fascicle) of muscle cells - Epimyseum is connective tissue (attached to tendon) that goes around the whole muscle - Endomysium -> Perimysium -> Epimysium -> Tendon -> Bone |
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Nerves of Skeletal Muscles
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- Neurons close to muscle cells
- Sends ACH to surface of muscle cell - Presence is detected by cell membrane of muscle, which transmits electrical impulse to make muscle contract |
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Motor Unit
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- A single motor neuron and the muscle fibers it innervates.
- # of muscle fibers per motor unit varies (1:10 eye, 1:500 quadriceps) - Each motor unit goes all or nothing, so the muscles with the smallest ratio have the most motor control |
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Muscle Organization
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Myofilaments (actin & myosin) -> Myofibril -> Muscle fiber -> Fasciculi -> Muscle
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Muscle Fibers
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-I bands (Light, actin only)
-A bands (dark, actin and myosin) - H zones (Light, actin only, Helles means light. in the center of A bands) |
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Types of Muscle Action
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- Isometric (length is staying the same, like the plank)
- Concentric (contract, getting shorter) - Eccentric (muscle is getting longer) - Strongest eccentrically |
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Types of Skeletal Muscle Fibers
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- Red Slow-twitch: Aerobic, slow oxydative. Abs, back muscles, things that are always active
- White Fast-twitch: Anaerobic, fast glycotic. Arms - Intermediate Fast-twitch: Aerobic, fast oxydative. Legs |
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Steroids
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- Hormones originally intended to increase weight gain for people who had cancer or anorexia.
- 70+ side effects: Acne, liver damage, roid rage, breast development, ossification of epiphyseal plates |
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Androstenedione
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- Precursor to testosterone and estrogen, converts to whichever exists in the body in lower levels.
- In young females increases testosterone, in young males increases estrogen. |
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Creatine
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- Protein that improves energy production
- Only supplement proven to improve performance |
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Cholestrum (colostrum)
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- Protein & growth hormone
- Present in mother's milk first few days of life - No evidence of any improvements |
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Parallel (Arrangement of Muscle Fascicles)
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- Fascicles run parallel to the long axis
- Long & flat, moves over a great distance, food endurance, not very strong - Sartorius, rectus abdominus |
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Convergent (Arrangement of Muscle Fascicles)
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- Wide origin & narrow insertion
- Force concentrated on a single point |
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Pennate (Arrangement of Muscle Fascicles)
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- Fascicles attach at an angle to a tendon that runs the length of the muscle
- Many fibers per unit area, tire quickly - Unipennate, bipennate, multipennate |
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Circular (sphincteral) (Arrangement of Muscle Fascicles)
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- Concentric arrangement around orfice
- Orbicularis Oculi, Orbicularis Oris |
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Muscle groups
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- Agonist (main mover)
- Synergist (helping mover) - Antagonist (works against the agonist) -Stabilizers & neutralizers (neutralizers remove an unwanted movement) |
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Sensory
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Afferent, to the CNS
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Motor
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Efferent, away from the CNS
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Somatic
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- Outside ventral body cavity (voluntary)
- Touch, pain, pressure, vibration, temperature, proprioception (sensory) - Contraction of skeletal muscles (motor) |
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Visceral
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- Inside the ventral body cavity (involuntary)
- Stretch, pain, temperature, taste (sensory) - Regulation of smooth and cardiac muscle contraction, ANS (autonomic nervous system) (motor) |
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Neurons
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- Basic structural & functional unit of the nervous system
- 100 year life span - Cannot reproduce, but may repair themselves - High metabolic rate (Glucose and O2) |
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Neurons v. Nerve Fibers v. Nerves
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- Neurons: Nerve cells
- Nerve fiber: axons - Nerve: Bundle of nerve fibers outside the CNS |
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Resting Potential
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- Of muscles, created by Na/K pump. 3 Na out for every 2 K in
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Transmission of Nerve Impulses
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- All or nothing
- Speed based on myelination (myelinated is faster) and diameter (larger diameter faster) - For myelinated fibers, speed is proportional to diameter. For unmyelinated fibers, speed is the square root of the diameter. |
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Structure of Neurons
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- 99% are multipolar
- Some are bipolar or unipolar |
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Neuroglia in the CNS
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- Astrocytes (Bind capillaries & neurons)
- Microglia (Phagocytize pathogens & debris) - Ependymal cells (Move cerebrospinal fluid by ciliary action) - Oligodendrocytes (Form myelin) |
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Neuroglia in PNS
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- Satellite cells (Support cell bodies in ganglia)
- Schwann cells (neurolemmocytes) (Form myelin) |
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White vs Grey matter
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- White: myelinated
- Grey: unmyelinated |
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Structure of Nerve
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- Endoneurium: around axons
- Perineurium: around fascicles - Epineurium: around whole structure |
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Reflex Arc
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Receptor -> sensory neuron -> integration center -> motor neuron -> effector
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Monosynaptic (stretch) Reflex
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- Reflex arc characteristics
- Monosynaptic so no integration center - Ipsilateral (means same side) |
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Withdrawal (flexor) Reflex
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- Reflex arc characteristics
- Polysynaptic, so there is an integration center - Ipsilateral |
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Crossed Extensor Reflex
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- Reflex arc characteristics
- Polysynaptic, integration center with crossing over - Ipsilateral and contralateral |
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Brain Facts
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- 3.3 lbs
- 100 billion neurons - High metabolic rate (20% of cardiac output, 10 second lapse = unconscious) |
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Ependymal Cells
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Pump cerebrospinal fluid (CSF) throughout CNS
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Cerebral Hemispheres
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- 83% of brain mass
- Higher mental functions like memory and reasoning - Cortex (outer part, grey matter) - Sulcus is cut in the brain (plural sulci) -Gyrus is bump in the brain (plural gyri) |
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Frontal Lobe of Brain
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- Voluntary Motor Control
- Higher intellectual processes - Verbal communication |
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Precentral Gyrus
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- Frontal lobe
- Motor |
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Parietal Lobe
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- Speech
- Emotions - Textures & shapes |
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Postcentral Gyrus
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- Parietal lobe
- Somatic sensory cortex |
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Temporal Lobe
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- Auditory
- Vestibular |
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Right Brain Control
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- Left control
- Creativity - Art - Music - Spatial -Construction |
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Left Brain Control
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- Right control
- Logic - Math - Science - Speech - Language - Writing |
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Broca's Area
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Motor Speech Area
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Wernicke's Area
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Language comprehension area
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Association fibers
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Myelinated neurons that connect sections of the brain within one hemisphere
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Commisural fibers
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Myelinated nerurons that cross between left and right hemispheres
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Projection fibers
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Run vertical and into the brainstem. Cross over
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Basal Ganglia
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- Start, stop, and regulate the intensity of voluntary movements
- May select appropriate muscles - Parkinson's Disease is related to this |
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Diencephalon
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Autonomic region (thalamus, hypothalamus, epithalamus, pituitary gland)
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Thalamus
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- Grey matter
- Relay center for all sensory impulses |
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Hypothalamus
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- Cardiovascular regulation and digestion
- Emotional responses - Body temperature regulation - Regulation of hunger and thirst - Behavior - Regulation of sleeping and wakefulness - Control of endocrine functions - Memory? |
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Epithalamus
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- Pineal body (gland)
- Melatonin |
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Pituitary Gland
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- Infundibulum
- Adenohypophysis (Anterior portion) - Neurohypophysis (Posterior portion) - Housed in sella turica |
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Midbrain
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- Corpora quadrigemina (superior colliculi: visual reflexes, track movement; inferior colliculi: auditory reflexes)
- Cerebral peduncles |
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Pons
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-Relays messages between cerebral and cerebellar hemispheres
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Medulla oblongata
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Visceral autonomic center (respiration, heart rate; one of the issues with upper spinal/neck injuries is that this could get damaged and you could stop breathing or your heart could stop)
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Cerebellum
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Coordinates skeletal muscle contractions
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Meninges
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- Dura mater (most superficial, external)
- Arachnoid mater (spiderweb, small, cerebrospinal fluid and blood vessels) - Dia mater (in direct contact with CNS tissue. MAkes it possible for sugar and oxygen to pass through - Meningitis: an inflammation of the meninges |
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Septa of cranial dura mater
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- Falx cerebri (vertical fold, separates right and left cerebral hemispheres)
- Falx cerebelli (vertical fold, separates right and left cerebellar hemispheres) - Tentorium cerebelli (horizontal fold separating cerebrum and cerebellum; like a tent over the cerebellar hemisphere) |
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Spinal Cord
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- 45 cm long (18 inches)
- 1-1.5 cm diameter - 31 sections (31 spinal nerves) - 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, 1 coccygeal |
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Spinal cord white and grey matter
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- Grey (signals side to side, unmyelinated, cell bodies)
- White (signals up and down, myelinated) -Central canal (cerebrospinal fluid through here) |
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Cranial Nerves
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I. Olfactory
II. Optic III. Oculomotor IV. Trochlear V. Trigeminal VI. Abducens VII. Facial VIII. Vestibulocochlear IX. Glossopharyngeal X. Vagus XI. Accessory XII. Hypoglossal |
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I. Olfactory
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- Function: Sensory
- Part: Smell - Hole: Olfactory foramina |
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II. Optic
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- Function: Sensory
- Part: Vision - Hole: Optic foramina |
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III. Oculomotor
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- Function: Motor
- Part: Medial rectus, superior rectus, inferior rectus, inferior oblique - Hole: Superior Orbital Fissure |
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IV. Trochlear
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- Function: Motor
- Part: Superior oblique - Hole: Superior Orbital Fissure |
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V. Trigeminal
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- Function: Both
- Part: Face, mouth, tongue (sensory); Chewing (motor) - Hole: Superior orbital fissure, foramen rotundum, foramen ovale - Largest diameter cranial nerve |
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VI. Abducens
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- Function: Motor
- Part: Lateral rectus - Hole: Superior Orbital Fissure |
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VII. Facial
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- Function: Both
- Part: Taste buds (sensory); Facial expressions (motor) - Hole: Stylomastoid foramen |
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VIII. Vestibulocochlear
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- Function: Sensory
- Part: Balance and hearing - Hole: Internal acoustic meatus |
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IX. Glossopharyngeal
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- Function: Both
- Part: Proprioception, taste buds (sensory); Swallowing (motor) - Hole: Jugular foramen |
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X. Vagus
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- Function: Both
- Part: From organs (sensory); Taste buds, viscera (motor) - Hole: Jugular foramen - Longest cranial nerve |
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XI. Accessory
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- Function: Motor
- Part: Neck muscles - Hole: Jugular foramen |
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XII. Hypoglossal
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- Function: Motor
- Part: Tongue - Hole: Hypoglossal canal |
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Spinal Nerves
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- 31 pairs (8 cervical, 12 thoracic, 5 lumbar, 5 sacral, 1 coccygeal)
- Dorsal root: Sensory (spinal ganglion) - Ventral root: Motor (axons) - Dorsal ramus: Muscles, skin along vertebral column - Ventral ramus: Muscles, skin on lateral and anterior portions; some combine to innervate limbs |
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Cervical Plexus
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- C1-C5
- Upper extremity |
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Axillary Nerve (Cervical Plexus)
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- Armpit, deltoid, and teres minor (motor)
- Skin over deltoid (sensory) |
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Radial Nerve (Cervical Plexus)
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- Posterior side of arm (motor)
- Posterior and lateral upper, forearm, hand (sensory) - Saturday night paralysis |
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Musculocutaneous (Cervical Plexus)
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- Elbow flexors: biceps brachium, brachialis, coracobrachialis (motor)
- Lateral forearm (sensory) |
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Ulnar (Cervical Plexus)
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- Lose strength in medial fist & finger flexors
- Funny bone nerve |
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Median (Cervical Plexus)
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- Lateral wrist and finger flexors (motor)
- Anterior and lateral hand (sensory) |
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Lumbar Plexus
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- L1-L4
- Lower abdomen and anterior/medial leg |
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Femoral Nerve (Lumbar Plexus)
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- Hip flexors & quads, anterior femur (motor)
- Anterior/medial thigh, leg, and foot (sensory) |
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Obturator Nerve (Lumbar Plexus)
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- Medial thigh, adductor (motor)
- Inner thigh (sensory) |
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Sacral Plexus
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- L4-S4
- Low back, pelvis, posterior leg, and foot |
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Sciatic Nerve (Sacral Plexus)
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- Tibial: backside of tibia, posterior muscles (motor); posterior & lateral leg and calf, plantar foot (sensory)
- Peroneal: anterior & lateral leg, dorsiflexors and peroneus longus/brevis, everters (motor); Anterior and lateral leg, dorsal foot (sensory) |
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Dermatome
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A topographical map of a person that tells which area of skin provides sensory info to spinal nerves
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Autonomic Nervous System (ANS)
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- A system of motor neurons that innervate the smooth muscle, cardiac muscle, and glands of the body.
- Involuntary - Maintains homeostasis by increasing or decreasing activity - Functions independently, no conscious control necessary |
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Voluntary (Somatic) Motor System
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- Skeletal muscles
- Single Axon - Cell bodies in CNS |
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Involuntary (Autonomic) Motor System
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- Smooth muscle, cardiac muscle, glandular epithelium
- Pre/post ganglionic neurons - Cell bodies in CNS and outside CNS |
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Sympathetic Division (ANS)
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- Increases activity
- Thoracolumbar - Preganglionic axons short and myelinated (white ramus communicans); postganglionic axons long and unmyelinated (grey ramus communicans) - Adregenergic effects - Pupil dilation; increases sweat, decreases saliva; increased heart rate; vascoconstriction; dilation of bronchioles; sphincters closed |
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Parasympathetic Division (ANS)
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- Decreases activity levels
- Craniosacral - Terminal ganglia, located on or near innervated organs. This means preganglionic axons are long and postganglionic axons are short - Energy conservation - Pupil constriction; increases tears, increases saliva; decreased heart rate; vascodilation (only back to normal size); constriction of bronchioles; sphincter closing inhibited |
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Blood Basics
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- Connective tissue (only fluid one)
- 8% of body weight - Comes from mesenchyme |
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Blood flow
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- Arterial blood: away from heart
- Venous blood: towards heart - Oxygenated blood: red - Deoxygenated blood: blue - Pulmonary (lungs) is reversed, arterial blood is deoxygenated (blue) and venous blood is oxygenated (red) |
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Blood Viscosity
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- Resistance to flow
- 4.5-5.5 - Compared to water, is thicker. Water is 1.0 |
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Blood Plasma
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- Albumins: add viscosity, thickness to blood; help regulate blood pressure and prevent leaks
- Globulins: made by liver; help transport fats and fat soluble vitamins (alpha and beta); antibodies of immunity (gamma) - Fibrinogen: works with thrombocytes to help form blood clots |
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Hematocrit
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% of blood volume made up of red blood cells; the average is 45%
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Erythrocytes
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- Red blood cells
- O2 and CO2 transport - Biconcave discs; unique shape increases surface area and allows for oxygen transport - No nucleus or mitochondira, so not a true cell - 100-120 day lifespan |
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Leukocytes
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- Only formed elements that are true cells (contain nuclei and mitochondria)
- Ameboid (can go outside circulatory system) - Nearly invisible under microscope |
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Neutrophils (Leukocytes)
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- Granular
- Nonstaining (neutral) - Lifespan: 6 hours to a few days - Phagocytic cells, eat foreign materials |
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Eosinophils (Leukocytes)
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- Granular
- Pink staining - Lifespan: 8-12 days - Phagocytic |
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Basophils (Leukocytes)
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- Granular
- Blue staining - Lifespan: A few hours to a few days - Phagocytic |
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Lymphocytes (Leukocytes)
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- Agranular
- Large nuclei & thin layer of cytoplasm - Lifespan: hours to years - T cells: killer; become aminocompetent in thymus - B cells: antibody producer; mature in bones |
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Monocytes (Leukocytes)
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- Agranular
- Largest cells in blood - Lifespan: months |
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Thrombocytes
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- Clot formation
- Smallest of formed elements - Are fragments of megakaryocytes - Ameboid (can leave circulatory system) - Lifespan: 5-10 days |
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Blood Clots
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- Thrombus: clot in a blood vessel
- Embolus: free floating thrombus |
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Hemopoesis
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- Process of forming blood cells
- Erythropoesis (RBCs) Leukopoesis (WBCs) - Starts with a blood stem cell - Committed cells can't change their mind about which cell type to become |
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Sites of Hemopoesis
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- Red marrow: always active. In spongy bone (epiphyses) of long bone or flat bones
- Yellow marrow: active only in emergencies, in the diaphysis of long bones |
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Heart
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- Continuously working pump (70-80 bpm)
- Weighs less than 1 lb - 3 layers of the wall: epicardium (serous membrane, also called visceral pericardium), myocardium (middle layer, muscle, does contracting), endocardium (endofilial layer [simple squamous] prevents leaks) |
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Blood Flow in Heart
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Right atrium -> Right ventricle -> Lungs -> Left Atrium -> Left Ventricle -> Out
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Right Atrioventricular Valve
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- Tricuspid
- Valve open when heart/ventricles relaxed - Valve closed when heart/ventricles contracting |
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Pulmonary Semilunar Valve
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- Moon-shaped flaps
- Valve open when heart contracting - Valve closed when heart relaxed |
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Left Atrioventricular Valve
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- Bicuspid (mitral)
- Valve open when heart relaxed - Valve closed when heart contracting |
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Aortic Semilunar Valve
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- Moon shaped flaps
- Valve open when heart contracting - Valve closed when heart relaxed |
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Blood Pressure
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- Force exerted against vessel walls (systole, diastole)
- 120/80 normal - 140/100 high - 100/60 low - Systolic is pressure on vessels when heart contracts - Diastolic is pressure left over when the heart relaxes - BP number is systolic/diastolic |
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Heart sounds
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- Lub-dub
- Sounds of valves closing - Lub is closing of AV valves - Dub is closing of semilunar valves |
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Circulatory Routes
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- Systemic cirulation (to the rest of body)
- Pulmonary circulation (to lungs) - Coronary circulation (for heart) |
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Myocardial Infarction
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- Heart attack
- Myocardial necrosis: thrombus formation in coronary artery -Surgical prevention: coronary bypass (72% success), angioplasty (inflate balloon in artery) |
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Blood Vessels
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- 35% of blood in arteries
- 65% of blood in veins - Structure permits blood flow & molecular exchange between blood and tissues - 3 layers: tunica interna (simple squamous), tunica media (smooth muscle), tunica externa (loose connective) |
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Arteries
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- Large: Elastic fibers in tunica media, allow changes in diameter
- Medium: Less elastic fibers and more smooth muscle in tunica media; fairly constant diameter - Arteriole: Poorly defined tunica externa & media |
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Veins
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- Large: Thickest layers compared to other veins
- Medium: Tunica media thin - Venule: no tunica media |
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Capillaries
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- Continuous: complete endothelial lining
- Fenestrated: perforated endothelial lining; in places like small intestine to absorb nutrients or kidneys for filtration - Sinusoidal: Most perforated; in spleen or liver |
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Blood Brain Barrier
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Prevents all but vital molecules from entering the brain. Some other things can enter, like drugs or alcohol
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Special Vessels
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- Aorta: largest diameter artery
- Great saphenous vein: Longest vein; used in coronary bypasses |
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Lymphatic System
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- Functions: Maintain fluid balance in tissues, absorb fats from digestive system, fight infection
- Organs: lymph nodes, spleen (recycle used red blood cells), thymus (location for lymphocytes to mature), tonsils (if something taken in is bad, they signal the rest of the lymphatic system) |
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Lymph
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- Interstitial fluid that has entered the lymphatic capillaries.
- Proteins, microorganisms, and absorbed fats. |
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Lymph Ducts
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- Thoracic: drains 75% of body
- Right Lymphatic: drains 25% of body |
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