Due to the controversy of using atypical and typical antipsychotic drugs on patients with chronic schizophrenia, this meta-analysis will focus on the debate over which type of drug helps reduce symptoms more effectively. Using the most common antipsychotics, haloperidol for typical antipsychotic and olanzapine for an atypical antipsychotic, results will be tabulated across a range of scientific studies to conclude which drug has a better outcome of effectiveness for schizophrenic patients. Using the Positive and Negative Syndrome Scale (PANSS), the results will be measured between the two types of drugs and their controls or baseline measurements. Subsections of this paper will evaluate the efficacy of haloperidol and olanzapine on their own
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Another study lasted 52 weeks and found that the olanzapine-treated patients had significantly more improvement compared to haloperidol-treated patients on the PANSS total scores, suggesting that olanzapine was more effective than haloperidol in reducing symptoms (Keefe, R.S. 2016). Just by considering these two studies, it is clear that there are some inconsistencies between them; this debate between typical and atypical antipsychotics is what this meta-analysis will aim to answer. The two sub questions that will be researched is if olanzapine and haloperidol will individually reduce positive and negative symptoms in schizophrenia patients using the PANSS scale. The overall question to be addressed is whether typical or atypical antipsychotics are more effective in reducing symptoms in patients with chronic schizophrenia by using the results found in the sub …show more content…
Crespo (2006) compared the effectiveness between olanzapine, risperidone, and haloperidol for 6 weeks and found that all three antipsychotics showed similar effectiveness in reducing severity of symptoms. However, olanzapine and risperidone found the most improvement in positive and negative symptoms according to the PANSS scores (Crespo,F, 2006). In contrast, the study conducted by Green et al. (2006) compared the effectiveness between olanzapine and haloperidol and found that after a two year study there was no baseline differences looking at the PANSS scores. Even though these two studies used the same antipsychotics to compare, the two studies showed different results. This could be due to the fact that one study was 6 weeks long while the other two years and the difference in amounts given to
Another study lasted 52 weeks and found that the olanzapine-treated patients had significantly more improvement compared to haloperidol-treated patients on the PANSS total scores, suggesting that olanzapine was more effective than haloperidol in reducing symptoms (Keefe, R.S. 2016). Just by considering these two studies, it is clear that there are some inconsistencies between them; this debate between typical and atypical antipsychotics is what this meta-analysis will aim to answer. The two sub questions that will be researched is if olanzapine and haloperidol will individually reduce positive and negative symptoms in schizophrenia patients using the PANSS scale. The overall question to be addressed is whether typical or atypical antipsychotics are more effective in reducing symptoms in patients with chronic schizophrenia by using the results found in the sub …show more content…
Crespo (2006) compared the effectiveness between olanzapine, risperidone, and haloperidol for 6 weeks and found that all three antipsychotics showed similar effectiveness in reducing severity of symptoms. However, olanzapine and risperidone found the most improvement in positive and negative symptoms according to the PANSS scores (Crespo,F, 2006). In contrast, the study conducted by Green et al. (2006) compared the effectiveness between olanzapine and haloperidol and found that after a two year study there was no baseline differences looking at the PANSS scores. Even though these two studies used the same antipsychotics to compare, the two studies showed different results. This could be due to the fact that one study was 6 weeks long while the other two years and the difference in amounts given to