3.1.1 ERG
One of the first reports of using ERG tracing was in 1988, where the oscillatory potentials (low amplitude, high frequency wavelets present on the ascending part of the b-wave, were looked at as a marker for dopaminergic disease. No difference was found in schizophrenic patients (N=12) versus the control group (N=9). The next ERG study was in 1992. While they did not find a significant difference in ERG tracing between their schizophrenia patients (N=9) versus their control group (N=13), they did notice a decreased cone b-wave in 6 of their schizophrenia patients with a history of sun gazing.
Since then, there have been more studies using the ERG as a probe for retinal disease in schizophrenic patients. A summary of these studies is shown below in Table 2. A pilot study used the ERG to measure retinal function as a marker for cell membrane omega-3 fatty acid depletion …show more content…
In addition to the findings shown below, they found no significant correlation between medication dose, in terms of chlorpromazine equivalents, and ERG measures. Of the 9 schizophrenic patients, one patient had been free of antipsychotic medication for over 6 months. In this patient, the dark adapted a-wave amplitude was comparable to the schizophrenic group (217.2 versus 215.1), the light adapted a-wave amplitude was intermediate between the groups (50.7 versus 40.0 in SZ and 56.6 in control), and both the dark and light adapted b-wave amplitudes were greater than the control group. These values are visualized in Figure 1. This was replicated by a subsequent study, which found a
One of the first reports of using ERG tracing was in 1988, where the oscillatory potentials (low amplitude, high frequency wavelets present on the ascending part of the b-wave, were looked at as a marker for dopaminergic disease. No difference was found in schizophrenic patients (N=12) versus the control group (N=9). The next ERG study was in 1992. While they did not find a significant difference in ERG tracing between their schizophrenia patients (N=9) versus their control group (N=13), they did notice a decreased cone b-wave in 6 of their schizophrenia patients with a history of sun gazing.
Since then, there have been more studies using the ERG as a probe for retinal disease in schizophrenic patients. A summary of these studies is shown below in Table 2. A pilot study used the ERG to measure retinal function as a marker for cell membrane omega-3 fatty acid depletion …show more content…
In addition to the findings shown below, they found no significant correlation between medication dose, in terms of chlorpromazine equivalents, and ERG measures. Of the 9 schizophrenic patients, one patient had been free of antipsychotic medication for over 6 months. In this patient, the dark adapted a-wave amplitude was comparable to the schizophrenic group (217.2 versus 215.1), the light adapted a-wave amplitude was intermediate between the groups (50.7 versus 40.0 in SZ and 56.6 in control), and both the dark and light adapted b-wave amplitudes were greater than the control group. These values are visualized in Figure 1. This was replicated by a subsequent study, which found a