Renin secretion is stimulated by decreased blood volume, decreased renal perfusion, sodium and water depletion. Subsequently, renin promotes the conversion of angiotensinogen to angiotensin I. Angiotensin I is then converted to angiotensin II through the angiotensin converting enzyme. Due to angiotensin II being a potent vasoconstrictor, it also stimulates aldosterone secretion leading to sodium and water retention. The subsequent renal retention of sodium and water, coupled with an increase in heart rate and contractility, ultimately leads to an increase in preload and afterload, which further contributes to pulmonary and vascular congestion which creates the cycle of symptoms of CHF (Fletcher & Thomas,
Renin secretion is stimulated by decreased blood volume, decreased renal perfusion, sodium and water depletion. Subsequently, renin promotes the conversion of angiotensinogen to angiotensin I. Angiotensin I is then converted to angiotensin II through the angiotensin converting enzyme. Due to angiotensin II being a potent vasoconstrictor, it also stimulates aldosterone secretion leading to sodium and water retention. The subsequent renal retention of sodium and water, coupled with an increase in heart rate and contractility, ultimately leads to an increase in preload and afterload, which further contributes to pulmonary and vascular congestion which creates the cycle of symptoms of CHF (Fletcher & Thomas,