Neurotransmission At Neeuromc Synapses Case Study
Diaz, Shanna., Borzoo, Farhang., (2009) Sex Differences in the Cannabinoid Modulation of Appetite, Body Temperature, and Neurotransmission at POMC Synapses. Neuroendocrinology, 89, 424-440 DOI: 10.1159/000191646. In this study conducted by Shanna Diaz et al., researchers were interested in determining whether sex differences exist for the cannabinoid modulation of appetite, body temperature, and neurotransmission at POMC synapses. The drugs that were used in this experiment were a 1 mg/kg s.c. agonist CB1 receptor WIN 55,212-2, a 3 mg/kg s.c. antagonist AM251, and a 1 ml/kg s.c. vehicle. This study had two parts to it with one focusing on the behavioral aspects of the animals and the other on the biological aspects. Behavioral aspects included five parameters of feeding that were monitored. The five parameters were: hourly intake, daily intake (24-hour period), meal size, meal frequency, and meal duration. It is important to bear in mind that the animals’ behavioral activities were only logged if the animal consumed a minimum of 10 mg of food by the time the head was withdrawn from the feeding bowl.
Tests were run on gonadectomized male and female guinea pigs and there were gonadally intact male and female CB1 receptor knockout mice and littermate controls. The guinea pigs …show more content…
The symptoms are usually more obvious once a long-term significant increase of calcium occurs. Hyperparathyroidism often shows itself through nonspecific and mild symptoms such as osteoporosis, kidney stones, abdominal pain, depression, excessive urination, loss of appetite, nausea, weakness, etc. Most of these symptoms were attributed to primary hyperparathyroidism but I think they can also be attributed to secondary as well. This probably makes it even harder to diagnose if it is primary or