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Developmental Biology journal homepage: www.elsevier.com/locate/developmentalbiology
Marker genes identify three somatic cell types in the fetal mouse ovary
Raphael H. Rastetter a,1, Pascal Bernard a,1, James S. Palmer b, Anne-Amandine Chassot c,d,
Huijun Chen b, Patrick S. Western e, Robert G. Ramsay f,g, Marie-Christine Chaboissier c,d,
Dagmar Wilhelm a,n a Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia
Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4075, Australia c University of Nice-Sophia Antipolis, UFR Sciences, Nice, …show more content…
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Ovaries develop from a bipotential anlage, the genital ridges, which arise as paired structures at the ventro-medial surface of the mesonephros at around 10 days post coitum (dpc) in mice.
Approximately half a day later, at 10.5 dpc, the male-determining gene Sry on the Y chromosome is up-regulated in XY genital ridges and drives differentiation into a testis. If Sry is not present, e.g. in an XX individual, or its expression or function is misregulated, the genital ridge will develop into an ovary (Warr and Greenﬁeld,
2012; Wilhelm et al., 2013). The differentiation of an ovary is actively driven by a number of genes, including Wnt4 (winglessrelated MMTV integration site 4)