How I Generation Sequencing Technology Changed The Study Of Polygenic Diseases

1738 Words 7 Pages
Recently, I was asked how Next Generation Sequencing technology may lead to significant advances in the study of polygenic diseases. As not being Biology my area of expertise, this question led to a lot of research. The first thing I did was to study the term polygenic, from which my first guess it was to mean “many genes” as poly- derives from the Greek meaning “much or many” and “genic” from gene, either the production of or to be related to genes (YourDictionary, 2013). Therefore, there was a chance of the term polygenic disease to describe a disease or illness related to a disorder in the gene or influenced by many genes.
Scientific literature defines a polygenic disease as an affliction that runs in the family, however, only a few members of the family exhibit that phenotype (Alberts, et al., 2008). But what is a phenotype? Well, Alberts, et al. defines phenotypes as a characteristic that can be observed from an individual or a living organism (cells). What is really interesting is that these characteristics can be either physical or behavioral (Alberts, et al., 2008) (T, Jasuja, & Sehgal, 2016)and that these by be affected by either environmental factors or genetic disorders (Kitchen, 2010). This means that those characteristics that define you such as your hair color, eye color, height, skin color and weight, among others, and if you are bipolar or suffer severe anxiety, including any disease or medical conditions, are characteristics defined by your phenotype that…

Related Documents