How Does Hydroxyurea Work To Treat Sickle Cell Anemia

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How Does Hydroxyurea Work To Treat Sickle Cell Anemia?

Problem: Suffering From Sickle Cell Anemia.
Sickle cell anaemia is a severe hereditary form of anaemia. Anemia is a condition where there is an inadequate amount of red blood cells or haemoglobin in the blood. HBB also known as haemoglobin beta or Beta globin is 146 amino acids long that makes up most of the haemoglobin in adult humans. HBB protein is produced by the gene HBB that is located in the multigene locus of β-globin locus on chromosome 11, specifically on the short arm position 15.5[18]. Mutation in the HBB gene can lead to the formation of hemoglobin S that results in sickle cell anaemia [2].

When oxygen levels are low in the blood, a mutated form of hemoglobin (hemoglobin
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Whereas those who took the placebo had painful crisis much sooner and the effect is apparent in less than 6 months.

This proves that Hydroxyurea is an effective solution in reducing pain infection and controlling complication.

One of the methods was to analyse the hematologic variables. This was appropriate because it enabled us to see the microscopic effects of Hydroxyurea. Also by given selected patients a placebo and other patient Hydroxyurea, allowed us to examine and differentiate what the drugs does in the human body and how the body responds to the drug. The scientists that carried out this experiment did not know whether patients were receiving a placebo or the real drug. This method was appropriate because it allowed scientist to treat each individual the same, therefore increasing the accuracy and reliability of the study.
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For instance the most common symptoms of Hydroxyurea can cause Cough or hoarseness, fevers or chills, lower or side pain and painful or difficult urination. This can be potentially dangerous, particularly in elder people who have SCD. The side effects may lead to an increase in hospitalization and the pain that patients may feel can have a huge impact on their daily lives. Therefore this must be considered when prescribing Hydroxyurea to someone with SCD. In addition. “A few children develop dermatologic changes, including skin hyperpigmentation or darkening of the nails which are sporadic and not dose-dependent” [13]. This can have a huge impact on children’s lives such as the way they think about themselves and their self-esteem. The drug has shown negative effects in young children taking Hydroxyurea to treat sickle cell anaemia as it diminishes growth rates. Unfortunately, there is a lack of recent significant data to oppose this and in addition to any serious side effects which may become apparent later on in life have not yet been

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