VI. Caffeine:
Caffeine “a cyclic nucleotide phosphodiesterase inhibitor” is obviously increased and preserves the respiration and motility of bovine spermatozoa (El-Gaafary, 1994). In several mammalian species, the necessary role of calcium on sperm capacitation has been proved (Yanagimachi, 1994), and an increase in intracellular Ca2+ concentration resulted in hyper-activation of the flagella (Ho and Suarez, 2001). Caffeine may act directly by influencing cellular metabolism, and its roles depend on the Ca +2concentration. It was acertain that positive effect of inhibiting phosphodiesterase activity may lead to an increase in intracellular cyclic adenosine monophosphate (cAMP), susequently increase of sperm motility (El-Menoufy et al., 1986).
Caffeine “a cyclic nucleotide phosphodiesterase inhibitor” is obviously increased and preserves the respiration and motility of bovine spermatozoa (El-Gaafary, 1994). In several mammalian species, the necessary role of calcium on sperm capacitation has been proved (Yanagimachi, 1994), and an increase in intracellular Ca2+ concentration resulted in hyper-activation of the flagella (Ho and Suarez, 2001). Caffeine may act directly by influencing cellular metabolism, and its roles depend on the Ca +2concentration. It was acertain that positive effect of inhibiting phosphodiesterase activity may lead to an increase in intracellular cyclic adenosine monophosphate (cAMP), susequently increase of sperm motility (El-Menoufy et al., 1986).