Bismuth Research Paper

997 Words 4 Pages
Bismuth is the 83rd chemical in the periodic table. It is found as a natural metal on the surface of the earth. Bi has a ground state electronic configuration of [Xe]4f145d106s26p3 and trivalent and pentavalent Bi, Bi(III) and Bi(V), respectively, are the two predominant oxidation states. [27] It was discovered over a thousand years ago but was often confused with tin and lead. It is a prevalent post transition metal, which chemically resembles arsenic or antimony. Bismuth is the most naturally diamagnetic element and has one of the lowest values of thermal conductivity among metals. [27]
Bismuth is a brittle metal with a white hue, however, an iridescent oxide may form on the surface showing many colors from yellow to blue. Bismuth has a spiral
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It is often recovered as a byproduct of metal mining and therefore is relatively cheap to purchase despite it rarity. [27]
It is generally non-toxic and non-carcinogenic which contrasts greatly with many elements that follow it closely on the periodic table, such as arsenic, lead and tin which all pose great health risks. The non-toxic nature of bismuth allows it to be used in the health and cosmetic industries. The most notable medical use of Bismuth is in the gastro relief medication Pepto-Bismol.
Bismuth has been used in many different drug forms. It is well known that bismuth interacts with
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It has been suggested that bismuth thiosemicarbazone or thiocarbohydrazone complexes may supply anti-cancer properties due to their rich co-ordination complexes. [29]
A Bi(III) complex developed with 2-acetylpyrazine N (4)-phenylthiosemicarbazone (HL), [Bi(L)(NO3)2(CH3OH)] (figure 13 below) was found to be active against some cancer cell lines however, it was found to be less active than using Cisplatin for K562 (leukemia) cells during a 24 h treatment. [29]
Other research conducted in the same year found another Bi(III) compound, 2-acetylpyridine, N (4)-pyridyl thiosemicarbazone (HL), [Bi(HL)(NO3)3], (figure 14 below) also possessed anticancer properties against many cell lines, including K562 (leukemia) and HeLa (cervical) lines. In contrast to his findings with the [Bi(L)(NO3)2(CH3OH)] complex, the 2-acetylpyridine, N (4)-pyridyl thiosemicarbazone complex exhibited very good cytotoxity (IC<10µM) and therefore, exhibited similar cytotoxity (1.8µM) to that of cisplatin.

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