Phlomis Umbrosa Essay

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Cancer is one of the most life-threatening diseases requiring a lot of development in cures and preventative therapies. A wide variety of anticancer drugs including those that directly or indirectly act on the cells causing cell death have been developed,. Nowadays, natural products have received increasing attention for their potential as novel cancer preventive and therapeutic agents [1,2].
Alzheimer’s disease (AD) is one of the most common causes of mental deterioration in elderly people. It is a progressive degenerative neurological disorder resulting in impaired memory and behavior. Several studies proposed that the degeneration of cholinergic neurons in the basal forebrain and the associated loss cholinergic neurotransmission in the cerebral
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Phlomis umbrosa is distributed in several countries of the Southeast Asia. The root of P. umbrosa has been traditionally used for the treatment of hemorrhage, bronchitis, cold, and bone fractures [6]. Previous phytochemical investigations of the genus Phlomis have shown that they contain phenolics, iridoids, flavonoids, phenylpropanoids, lignans, neolignans, diterpenoids, alkaloids, and essential oils [5–8]. The separation and determination of the active constituents in medicinal plant extracts represent a viable method to achieve standardization and quality control. However, the research on the quantification of multifarious constituents in complex extracts from Phlomis species has not been developed. Recently, the chemical constituents of P. umbrosa have been investigated for their interesting and significant bioactivities. In this study, we describe the isolation, structural elucidation, quantification analysis, and anticancer and AChE activities of the isolated compounds from P. …show more content…
The inhibitory process was assessed by MTT assay. According to the results (Table 2) compound 8 showed significant cytotoxic effect with an IC50 value of 18.6 ± 2.0 μM. Compounds 6 and 9 displayed moderate cytotoxic activity with the IC50 values of 35.4 ± 3.1 and 42.9 ± 3.0 μM, respectively. Meanwhile, compounds 1‒5, 7, 8, and 10 were inactive (IC50 values > 100μM). These compounds were also tested against MCF-7 and HeLa cell lines. However, all the isolates were very week or inactive (IC50 value > 100 μM) (Table

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