Abstract: Neuropathic pain (NP) remains the most frequent cause of suffering and disability around world. Paeoniflorin (PF), a water-soluble monoterpene glycoside extracted from the roots of Paeonia lactiflora Pall, has a wide range of pharmacological functions. Neuroprotective effect of PF has been demonstrated in animal models of neuropathologies, however, its mechanism is still poorly understood. The aim of this study was to investigate whether PF could alleviate neuropathic pain and further explored its possible mechanism. We investigated the effect of PF on NP induced by chronic constriction injury (CCI) in the rat model. We had found that PF significantly attenuated CCI-induced neuropathic pain behaviors (thermal hyperalgesia and mechanical allodynia) and decreased the levels of proinflammatory
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Many plants have been proven effective for antagonizing chronic neuropathicpain(Kim, et al.,2009; Gao, et al.,2013; Zhou, et al.,2014). Paeoniae alba Radix, the dried roots of Paeonia lactiflora Pallas or Paeonia veitchii Lynch, is one of the Chinese traditional crude drugs herbs. It has been widely used in traditional Chinese prescriptions to alleviate various disorders(Wu, et al.,2010). Paeoniflorin (Figure 1), a monoterpene glycoside, is one of the principal active ingredients of Paeoniae alba Radix, which has been reported to exhibit many pharmacological effects such as, anti-inflammatory, anti-oxidant and neuroprotective effects(Zhong, et al.,2009; Guo, et al.,2012; Nam, et al.,2013; Wu, et al.,2013). Especially for nervous disorders, PF has been reported to exert neuroprotective actions against Alzheimer’s disease, cerebral ischemia, and Parkinson’s disease in experimental models (Liu, et al.,2006; Guo, et al.,2012; Zhang, et al.,2015). However, no reports have been published on analgesic properties of PF in neuropathic
Many plants have been proven effective for antagonizing chronic neuropathicpain(Kim, et al.,2009; Gao, et al.,2013; Zhou, et al.,2014). Paeoniae alba Radix, the dried roots of Paeonia lactiflora Pallas or Paeonia veitchii Lynch, is one of the Chinese traditional crude drugs herbs. It has been widely used in traditional Chinese prescriptions to alleviate various disorders(Wu, et al.,2010). Paeoniflorin (Figure 1), a monoterpene glycoside, is one of the principal active ingredients of Paeoniae alba Radix, which has been reported to exhibit many pharmacological effects such as, anti-inflammatory, anti-oxidant and neuroprotective effects(Zhong, et al.,2009; Guo, et al.,2012; Nam, et al.,2013; Wu, et al.,2013). Especially for nervous disorders, PF has been reported to exert neuroprotective actions against Alzheimer’s disease, cerebral ischemia, and Parkinson’s disease in experimental models (Liu, et al.,2006; Guo, et al.,2012; Zhang, et al.,2015). However, no reports have been published on analgesic properties of PF in neuropathic