Thalidomide is used as a drug to treat several illnesses [3]. Its molecular formula is C13H10N2O4 [1] and IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione [1]. Thalidomide contains a benzene and two rings, the left ring is believed to contain teratogenic effects and the right ring is responsible for hypnotic properties as it resembles the structure of similar drugs [9]. To continue, a small difference in R+ to the S- conformation changes thalidomide’s toxicity [9]. The former conformation has anti-inflammatory properties while the latter has been correlated to tumor formation [8]. Thalidomide is unstable in solutions and can spontaneously hydrolyze when over 6.0 pH [11]. The same action will occur to individuals administered thalidomide as enzymes in liver metabolize the safe
…show more content…
Thalidomide was first created by a German pharmaceutical company in 1954 and distributed in several markets in 1956 [2]. It was used as an ingredient to treat respiratory infections [3]. In 1957, thalidomide alone, was marketed globally to 46 countries as a sedative relieving nausea and morning sickness for pregnant women[5]. Its common name in Canada was Thalomid and it was known as the “wonder drug” [4]. It came in the physical form of white powder and taken orally[1]. The drug was also odorless as well as tasteless [7]. Samples of thalidomide was given to Canadians in 1959 but the drug officially entered the market in late 1961[3]. The cost ranged of one prescription ranged near 0.75 cents and in some countries, Thalomid was purchasable without the need of a doctor’s authorization[5]. Thalomid had
Thalidomide was first created by a German pharmaceutical company in 1954 and distributed in several markets in 1956 [2]. It was used as an ingredient to treat respiratory infections [3]. In 1957, thalidomide alone, was marketed globally to 46 countries as a sedative relieving nausea and morning sickness for pregnant women[5]. Its common name in Canada was Thalomid and it was known as the “wonder drug” [4]. It came in the physical form of white powder and taken orally[1]. The drug was also odorless as well as tasteless [7]. Samples of thalidomide was given to Canadians in 1959 but the drug officially entered the market in late 1961[3]. The cost ranged of one prescription ranged near 0.75 cents and in some countries, Thalomid was purchasable without the need of a doctor’s authorization[5]. Thalomid had