Animal researches have been conducted in complementary therapies and laboratory experiments to improve and protect human health and physiology. In spite of our increasing knowledge about the animal models of anxiety and the mechanisms of anti- anxiety treatments, there are some unmet clinical needs like the high rate of lack of response to anxiety. Thus, preclinical studies still have primary importance in this area of research. Animal models are widely used in medical studies which are impractical or impossible to be carried on human, and they have significant implications in search of new and better treatment strategies. In this paper, animal models of anxiety disorders and how they are truly relate to study human disorders used in preclinical
