Step 1 - Pharm - Reproductive Drugs

Front 1

MOA of finasteride (propecia)

Back 1

5-alpha-reductase inhibitor. For BPH and male-pattern baldness

Front 2

MOA of flutamide

Back 2

Nonsteroidal, competitive testosterone receptor blocker

Front 3

Clinical use of flutamide

Back 3

Prostate carcinoma

Front 4

MOA of ketoconazole

Back 4

Inhibits steroid synthesis

Front 5

MOA of spironolactone

Back 5

Inhibits steroid binding

Front 6

Side effects of finasteride

Back 6

Gynecomastia ("To prevent male-pattern baldness, give a drug that encourages female breast growth")

Front 7

These drugs are used in the treatment of PCOS to prevent hirsutism

Back 7

Ketoconazole, spironolactone

Front 8

These drugs have as their side effects gynecomastia and amenorrhea

Back 8

Ketoconazole, spironolactone

Front 9

MOA of leuprolide

Back 9

GnRH analog. Agonist when used pulsatile, antagonist when given continuously

Front 10

These are the antiandrogens

Back 10

Finasteride (5a-reductase blocker), flutamide (testosterone receptor antagonist), ketoconazole, spironolactone

Front 11

Uterine fibromas are treated with this drug

Back 11

Leuprolide

Front 12

These drugs are given to treat prostate cancer

Back 12

Flutamide, leuprolide (continuous)

Front 13

Side effects of leuprolide

Back 13

Antiandrogenic effects, n/v

Front 14

These drugs can be used to treat infertility

Back 14

Leuprolide (pulsatile), clomiphene (in PCOS)

Front 15

MOA of sildenafil

Back 15

Inhibit cGMP phosphodiesterase. Increased levels of cGMP promote corpus cavernosum smooth muscle relaxation

Front 16

MOA of vardenafil

Back 16

Inhibit cGMP phosphodiesterase. Increased levels of cGMP promote corpus cavernosum smooth muscle relaxation

Front 17

These drugs can cause impaired blue-green color vision

Back 17

Sildenafil, vardenafil

Front 18

These drugs can cause life-threatening hypotension when given with nitrates

Back 18

Sildenafil, vardenafil

Front 19

These drugs can cause headache, flushing and dyspepsia

Back 19

Sildenafil, vardenafil

Front 20

MOA of mifepristone

Back 20

Progesterone receptor blocker

Front 21

MOA of misoprostol

Back 21

PGE1 analog. Given with mifepristone to terminate pregnancy

Front 22

Side effect of mifepristone

Back 22

Heavy bleeding, GI effects (n/v, anorexia, abdominal pain)

Front 23

MOA of oral contraceptives

Back 23

Prevent estrogen surge and therefore also the LH surge; ovulation does not occur

Front 24

Side effects of OCPs

Back 24

Hypercoagulability, increased triglycerides; depression, weight gain, nausea, hypertension

Front 25

The side effects of this drug include increased triglycerides and hypercoagulability

Back 25

Oral contraceptives (synthetic progestins, estrogen)

Front 26

These drugs are protective against endometrial and ovarian cancer

Back 26

Oral contraceptives (synthetic progestins, estrogen)

Front 27

Possible side effets of HRT

Back 27

Increased risk of cardiovascular events

Front 28

Side effects of estrogen replacement therapy

Back 28

Endometrial cancer (thus they are always given with progesterone); thrombi

Front 29

MOA of dinoprostone

Back 29

PGE2 analog. Induces labor. Causes cervical dilation, uterine contraction.

Front 30

MOA of ritodrine

Back 30

Beta-2 agonist. Relaxes uterus, reduces premature uterine contractions

Front 31

MOA of terbutaline

Back 31

Beta-2 agonist. Relaxes uterus, reduces premature uterine contractions

Front 32

MOA of anastrozole

Back 32

Aromatase inhibitor. Used in post-menopausal women with breast cancer

Front 33

MOA of exemestane

Back 33

Aromatase inhibitor. Used in post-menopausal women with breast cancer

Front 34

This drug is given to induce labor

Back 34

Dinoprostone (PGE2 analog)

Front 35

These drugs are given to reduce premature uterine contractions

Back 35

Ritodrine, terbutaline

Front 36

These drugs are given in postmenopausal women with breast cancer

Back 36

Anastrozole, exemestane (aromatase inhibitors)

Front 37

This drug is given to promote recovery after burn or injury by stimulating anabolism

Back 37

Methyltestosterone

Front 38

T/F: Methyltestosterone can be used to treat breast cancer

Back 38

True. Given to treat ER-postitive breast cancer

Front 39

Side effects of methyltestosterone

Back 39

Reduces intratesticular testosterone in males by inhbiting Leydig cells. Gonadal atrophy. Increased LDL and decreased HDL.

Front 40

T/F: Giving testosterone can reduce the size of the testes

Back 40

True. Excess testosterone inhibits LH, so there is less activity in the testes

Front 41

Side effect of DES

Back 41

Clear cell adenocarcinoma of vagina in females exposed to DES in utero

Front 42

Contraindication of estrogens

Back 42

ER-postive breast cancer

Front 43

Clinical uses of estrogens (ethyinyl estradiol, DES, mestranol)

Back 43

Hypogonadism or ovarian failure; men with androgen-dependent prostate cancer

Front 44

Actions of progestins

Back 44

Reduce growth and increase vascularization of the endometrium

Front 45

Clinical uses of progestins

Back 45

Endometrial cancer, abnormal uterine bleeding, OCP

Front 46

MOA of clomiphene

Back 46

Partial agonist at hypothalamic estrogen receptors, preventing feedback inhibition and thus increasing release of LH and FSH from pituitary. Stimulates ovulation.

Front 47

This drug may cause visual disturbances

Back 47

Clomiphene

Front 48

This drug may cause multiple simultaneous pregnancies

Back 48

Clomiphene