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2 Cards in this Set
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Aspirin
1. Mechanism 2. Clincal Use 3. Toxicity |
1. IRREVERSIBLY inhibits cyclooxygenase (COX-1 and COX-2) by covalent binding, which decreases synthesis of both thromboxane and prostaglandins
2. Low dose --> decrease PLT aggregation, Medium dose --> antipyretic and analgesic, High dose --> anti-inflammatory 3. Gastric upset. Chronic use can lead to acute renal failure, interstitial nephritis, and upper GI bleeding. REYES SYNDROME in kids with viral infection. |
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NSAIDs (give examples)
1. Mechanism 2. Clinical Use 3. Toxicity |
ex: ibuprofen, naproxen, indomethacin, ketorolac
1. Reversibly inhibit cyclooxygenase (both COX-1 and COX-2). Block prostaglandin and thromboxane synthesis. 2. Antipyretic, analgesic, anti-inflammatory. INDOMETHACIN used to close a PDA. 3. Renal damage, fluid retention, aplastic anemia, GI distress, ulcers. |
