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20 Cards in this Set
- Front
- Back
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exocrine duties of pancreas |
- secretions that go into gut, most enzymes, secretes HCO3- for neutralization in duodenum |
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endocrine duties of pancreas |
- produces hormones that regulate entire body like insulin |
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anatomy of endocrine and exocrine |
- exocrine into duct for drainage onto epithelial (apical) surface - endocrine: epithelial basolateral surface into blood |
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acinar cells secrete what duct cells secrete what |
digestive enzymes- EXOcytosis H2O and HCO3- |
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pancreatic juices (3, are what and contains what) |
alkaline, isotonic contains electrolytes contains digestive enzymes |
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acid tide and alkaline tide |
acid tide: pancreatic making H into the blood (HCO3 in lumen on other side) alkaline tide: parietal opposite |
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proteases function |
digest proteins in peptides and amino acids |
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amylolytic enzyme |
digest starch into sugars |
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lipases |
digest triglycerides and free fatty acids and monoglycerides |
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nucleases |
digest nucleic acids into free nucleotids |
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acinar cells synthesize and package ... |
pro-enzymes into zymogengranules and are stored at the apical pole of the cell |
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-most secreted cells are inactive but activated in the ... and in which membrane -which enzyme activated them |
duodenum, luminal membrane - enterokinase |
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enterokinase cleaves _____ into ______ (which is what kind of enzyme) |
trypsinogen into trypsin, it is a protease (which also activates other proteases) |
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trypsin inhibitors made in the pancreas do what |
antagonize any prematurely activated enzymes (before the intestine) - trypsin can degrade itself if activated too early |
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which channel is affected in cystic fibrosis - what happens |
HCO3/Cl - HCO3 and water secretions in minimal, enzymes don't get flushed from ducts (don't reach intestine) - can result in pancreatic autodigestion |
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3 regulation processes in pancreatic juice secretions -acid in duodenum, -digested fat/protein in upper small intestine - parasympathetic |
-stimulate S cells to secrete secretin into the blood to stimulate HCO3 from the duct - I cells to secrete CCK into the blood to stimulate enzyme secretion in acinus - PS to release ACh |
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CCK regulation |
-fatty acids/amino acids stimulate CCK in small intestine to blood stimulates... -higher enzyme secretion in pancreas -gall bladder contraction = bile for fat breakdown, relaxation of sphincter of Oddi - fatty acids/amino acids absorbed- negative feedback |
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HCO3 regulation |
-acid enters duodenum from stomach= release secretin from small intestine secretin stimulates... -pancreatic duct cells to stimulate HCO3 -liver duct cells to stimulate HCO3 -neutralization negative feedback |
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secretin and CCK both... which results in what (2) |
-inhibit gastrin -reduced stomach motility=slows stomach emptying -reduced acid secretion |
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3 phases of pancreatic secretion |
cephalic gastric- minor but distention stimulate section by PS nerve intestinal- major. Acid in stomach= secretin, fat and protein in duedenum- CCK |
