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12 Cards in this Set
- Front
- Back
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What is the MOA of Digitalis?
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Inhibiting the Na/K ATPase causing increased Ca exchange into the cell
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What are the effects of Digitalis?
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Decreases ESV and EDV-->
Increases CO-->Increases renal perfusion-->reduces sympathetic tone |
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What is a side effect of Digitalis?
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DAD's (increased Ca+)
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When are Isoproterenol or Dobutamine used?
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These drugs are B agonists. They are used in acute HF.
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What is the MOA of Isoproterenol and Dobutamine in HF?
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Increases Ca+ uptake, increased rate
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What are the names of two phosphodiesterase (PDE) inhibitors used in HF
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Amirinone
Milrinone |
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What is the MOA of the PDE inhibitors?
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PDE degrages cAMP. By inhibiting it, you are in effect increasing cAMP levels much like in B agonists.
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What is the use of furosamide in CHF?
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Reduce edema. Remember that hypokalemia + digoxin = increaded dig effects
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What is the use of vasodilators in CHF (nitrates, ACEi, ARB's)
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To reduce the afterload strain on the heart
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What are 3 commonly used vasodilators in CHF
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Minoxidil
Hydralazine Prazocin |
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What classes of drugs are recommended as a cocktail for a CHF patient
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Diuretics(furosamide), ACEi (nitrates/ARB's second choice), Digoxin, B blockers
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In acute HF what is a major difference from chronic HF?
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You dont give B-Blockers in acute HF, they have an effect on prevention of remodeling in CHF
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