Oral Pathology

Front 1

Is Fibrous Dysplasia a true neoplasm?

Back 1

NO

Front 2

What type of mutation is FD?

Back 2

GNAS1

Front 3

How many types of FD are there? What are they?

Back 3

there are 3 types
.
monostotic - limited to ONE bone.
polyostotic - affects many bones.
craniofacial - a mix of the the 2. could affect maxilla and into the zygoma a little bit. technically this is 2 bones but since it is so close to the maxilla, it behaves more like 1 bone -- so this is termed craniofacial.

Front 4

Define the appearance of FD radiographically

Back 4

1. ground glass appearance
2. narrowed PDL space and ill defined lamina dura.
3. expanded cortex, often lesional bone.
4. not well demarcated borders.
5. fusiform or ovoid growth
6. hockey stick deformity.

Front 5

Name 2 syndromes associated with Fibrous dysplasia

Back 5

1. McCune Albright (polyostotic, endocrinopathies: precocious sexual development, pituitary adenoma, hyperthyroid)

2. Jaffe-Lichenstein - polyostotic.

both have cafe au lait pigmentation.

Front 6

Define the appearance of FD histopathologically

Back 6

Histopathologic Features
– Irregular trabeculae of bone in a fibrous stroma
– Trabeculae are not connected to one another
– No osteoblastic rimming
– May resemble “Chinese characters”
– Fuse directly to adjacent normal bone

Front 7

How is Osteoma related to Gardner's? What is the difference?

Back 7

Osteoma is a symptom of Gardner's Syndrome. Gardners has malignant colonic polyps while Osteoma is benign.

Front 8

Name some manifestations of Gardner's syndrome

Back 8

Osteoma: arise in puberty
• Supernumerary teeth
• Impacted teeth
• Epidermoid cysts
• Desmoid tumors
• Thyroid carcinoma

Front 9

How is osteoma treated? Prognosis?

Back 9

Treatment
– Conservative surgical excision vs. periodic observation
– Condylar osteoma usually removed surgically

Prognosis
– Do not recur
– No reported malignant transformation

Front 10

How is Gardner's treated?

Back 10

Colectomy

Front 11

What are the size differences b/w osteoid osteoma and osteoblastoma?

Back 11

osteoblastoma: > 2cm
osteoid osteoma: < 2 cm
agressive osteoblastoma: > osteoblastoma

Front 12

which lesions have radiolucent rims?

Back 12

cementoblastoma
CODs
odontoma (complex/compound)
familial gigantiform cementoma

Front 13

where is a cementoblastoma usually found?

Back 13

1st permanent mandibular molar (50%)

Front 14

where is chondroma usually found? what is it?

Back 14

Benign neoplasm of hyaline cartilage
• Found in bones of hands and feet most commonly
• May be easily misdiagnosed
• Clinical Features
– Arise in 3rd and 4th decades
– Usually found in condyle or anterior maxilla
– Painless, slow growing tumors
– May move teeth and resorb roots

Front 15

what 2 syndromes are chondroma associated with?

Back 15

• Ollier disease: multiple, unilateral lesions
• Maffucci syndrome: skeletal chondromatosis, soft tissue
angiomas

Front 16

what gene mutation is involved in Ewing's sarcoma?

Back 16

Neuroectodermal malignancy
(translocation)

– t(11;22)

Front 17

name some radiographic and histopathologic features of Ewing's Sarcoma

Back 17

• Radiographic Features
– Ill defined, radiolucent area
– May have cortical destruction or expansion
– “Onionskin” common in long bones but rare in jaws

• Histopathologic Features
– Small, round cells
– May contain glycogen
– Immunohistochemical studies show CD99 reaction
– Gene studies for translocation

Front 18

what is the most common FIBRO OSSEOUS lesion of the jaw?

Back 18

Cemento Osseous Dysplasia

Front 19

considered to be the most common lesion in the jaw..?

Back 19

metastatic tumors to the jaw. "numb chin syndrome" -- lesion can affect inf. alveolar nerve leading to numb chin syndrome.

Front 20

describe the genetic defect in Gorlin syndrome.

Back 20

Nevoid basal cell carcinoma syndrome (Gorlin syndrome) is an autosomal dominant inherited condition that exhibits high penetrance and variable expressivity. It is caused by mutations in patched (PTCH), a tumor suppressor gene that has been mapped to chromosome 9q22.3-q31.

Front 21

what is similar to gingival cyst of the adult and where is it clinically found?

Back 21

lateral periodontal cyst (its bony counterpart).

Like the lateral periodontal cyst, the gingival cyst of the adult shows a striking predilection to occur in the mandibular canine and premolar area (60% to 75% of cases).