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21 Cards in this Set

  • Front
  • Back
Is Fibrous Dysplasia a true neoplasm?
What type of mutation is FD?
How many types of FD are there? What are they?
there are 3 types
monostotic - limited to ONE bone.
polyostotic - affects many bones.
craniofacial - a mix of the the 2. could affect maxilla and into the zygoma a little bit. technically this is 2 bones but since it is so close to the maxilla, it behaves more like 1 bone -- so this is termed craniofacial.
Define the appearance of FD radiographically
1. ground glass appearance
2. narrowed PDL space and ill defined lamina dura.
3. expanded cortex, often lesional bone.
4. not well demarcated borders.
5. fusiform or ovoid growth
6. hockey stick deformity.
Name 2 syndromes associated with Fibrous dysplasia
1. McCune Albright (polyostotic, endocrinopathies: precocious sexual development, pituitary adenoma, hyperthyroid)

2. Jaffe-Lichenstein - polyostotic.

both have cafe au lait pigmentation.
Define the appearance of FD histopathologically
Histopathologic Features
– Irregular trabeculae of bone in a fibrous stroma
– Trabeculae are not connected to one another
– No osteoblastic rimming
– May resemble “Chinese characters”
– Fuse directly to adjacent normal bone
How is Osteoma related to Gardner's? What is the difference?
Osteoma is a symptom of Gardner's Syndrome. Gardners has malignant colonic polyps while Osteoma is benign.
Name some manifestations of Gardner's syndrome
Osteoma: arise in puberty
• Supernumerary teeth
• Impacted teeth
• Epidermoid cysts
• Desmoid tumors
• Thyroid carcinoma
How is osteoma treated? Prognosis?
– Conservative surgical excision vs. periodic observation
– Condylar osteoma usually removed surgically

– Do not recur
– No reported malignant transformation
How is Gardner's treated?
What are the size differences b/w osteoid osteoma and osteoblastoma?
osteoblastoma: > 2cm
osteoid osteoma: < 2 cm
agressive osteoblastoma: > osteoblastoma
which lesions have radiolucent rims?
odontoma (complex/compound)
familial gigantiform cementoma
where is a cementoblastoma usually found?
1st permanent mandibular molar (50%)
where is chondroma usually found? what is it?
Benign neoplasm of hyaline cartilage
• Found in bones of hands and feet most commonly
• May be easily misdiagnosed
• Clinical Features
– Arise in 3rd and 4th decades
– Usually found in condyle or anterior maxilla
– Painless, slow growing tumors
– May move teeth and resorb roots
what 2 syndromes are chondroma associated with?
• Ollier disease: multiple, unilateral lesions
• Maffucci syndrome: skeletal chondromatosis, soft tissue
what gene mutation is involved in Ewing's sarcoma?
Neuroectodermal malignancy

– t(11;22)
name some radiographic and histopathologic features of Ewing's Sarcoma
• Radiographic Features
– Ill defined, radiolucent area
– May have cortical destruction or expansion
– “Onionskin” common in long bones but rare in jaws

• Histopathologic Features
– Small, round cells
– May contain glycogen
– Immunohistochemical studies show CD99 reaction
– Gene studies for translocation
what is the most common FIBRO OSSEOUS lesion of the jaw?
Cemento Osseous Dysplasia
considered to be the most common lesion in the jaw..?
metastatic tumors to the jaw. "numb chin syndrome" -- lesion can affect inf. alveolar nerve leading to numb chin syndrome.
describe the genetic defect in Gorlin syndrome.
Nevoid basal cell carcinoma syndrome (Gorlin syndrome) is an autosomal dominant inherited condition that exhibits high penetrance and variable expressivity. It is caused by mutations in patched (PTCH), a tumor suppressor gene that has been mapped to chromosome 9q22.3-q31.
what is similar to gingival cyst of the adult and where is it clinically found?
lateral periodontal cyst (its bony counterpart).

Like the lateral periodontal cyst, the gingival cyst of the adult shows a striking predilection to occur in the mandibular canine and premolar area (60% to 75% of cases).