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22 Cards in this Set

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Embryonic Origin of Connective Tissue

Mesoderm

5 Functions of Connective Tissue

Structural Support


Medium for nutrient/waste exchange


Defense/Protection Body


Energy Storage


Repair after injury

Preprocollagen compostition

Glycine, Proline, Hydroxyproline, hydroxylysine

Collagen Formation

3 preprocollagen molecules align and from a helical procollagen molecule




At secretion procollagen peptidases remove terminal protein making tropocollagen




Tropocollagen polymerizes to form fibrils




Fibrils polymerize to form collagen fibers

Reticular fibers are covered by

Glycoprotein coat

Do Elastic Fibers have hydroxylysine

No

Desmosine

For lysine molecules of different elastin chains covalently bond. Imparts elasticity

Fibrillin

Forms microfibrils surrounding elastin

Formation of Elastic Fibers

Fibrillin microfibrils laid down


Elastin deposited on the microfibrils

Enzyme that breaks down elastin

Pancreatic elastase

Ground substance composition

Water


Glycosaminoglycans (GAGs)


Proteoglycans


Multiadhesive glycoproteins



Function of Ground substance

Lubricates and acts as a barrier to invaders

How do GAGs resist compression

Negative charge attracts water and repels each other making things slippery



Aggrecan

Proteoglycan responsible for the gel state of the EMC and acts as diffusion barrier

Glycoprotein function

Allow cell and other things to attach to ECM. Cells attach through integrins




Mediate interactions between cells

Examples of Glycoproteins (2)

Laminin and Fibronectin

Ehlers-Danlos Syndrome

Stops Hydroxylation of Lysine and inhibits Proteases cleaving ends


Leads to increased Skin elasticity and potential eyeball rupture

Dermatosparaxis

Inhibits proteases the cleave ends


Thin skin

Hereditary Equine Regional Derma Asthenia (HERDA)

Linked to protein mutations in procollagen chaperoning


Specific for dermal layer

Marfan Syndrome

Reduced amount of fibrillin and therefore elastic fibers

Cutaneous Mucinosis

Makes more GAGs and hyalonic acid


Only in dermis


Increases hyaluronian synthesis enzyme



3 characteristics of a Tendon

DRCT


Boxcar effect/arrangement


Basophilic streaming