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22 Cards in this Set

  • Front
  • Back

Embryonic Origin of Connective Tissue


5 Functions of Connective Tissue

Structural Support

Medium for nutrient/waste exchange

Defense/Protection Body

Energy Storage

Repair after injury

Preprocollagen compostition

Glycine, Proline, Hydroxyproline, hydroxylysine

Collagen Formation

3 preprocollagen molecules align and from a helical procollagen molecule

At secretion procollagen peptidases remove terminal protein making tropocollagen

Tropocollagen polymerizes to form fibrils

Fibrils polymerize to form collagen fibers

Reticular fibers are covered by

Glycoprotein coat

Do Elastic Fibers have hydroxylysine



For lysine molecules of different elastin chains covalently bond. Imparts elasticity


Forms microfibrils surrounding elastin

Formation of Elastic Fibers

Fibrillin microfibrils laid down

Elastin deposited on the microfibrils

Enzyme that breaks down elastin

Pancreatic elastase

Ground substance composition


Glycosaminoglycans (GAGs)


Multiadhesive glycoproteins

Function of Ground substance

Lubricates and acts as a barrier to invaders

How do GAGs resist compression

Negative charge attracts water and repels each other making things slippery


Proteoglycan responsible for the gel state of the EMC and acts as diffusion barrier

Glycoprotein function

Allow cell and other things to attach to ECM. Cells attach through integrins

Mediate interactions between cells

Examples of Glycoproteins (2)

Laminin and Fibronectin

Ehlers-Danlos Syndrome

Stops Hydroxylation of Lysine and inhibits Proteases cleaving ends

Leads to increased Skin elasticity and potential eyeball rupture


Inhibits proteases the cleave ends

Thin skin

Hereditary Equine Regional Derma Asthenia (HERDA)

Linked to protein mutations in procollagen chaperoning

Specific for dermal layer

Marfan Syndrome

Reduced amount of fibrillin and therefore elastic fibers

Cutaneous Mucinosis

Makes more GAGs and hyalonic acid

Only in dermis

Increases hyaluronian synthesis enzyme

3 characteristics of a Tendon


Boxcar effect/arrangement

Basophilic streaming