Connective Tissue Lecture 1 Histology

Front 1

Embryonic Origin of Connective Tissue

Back 1

Mesoderm

Front 2

5 Functions of Connective Tissue

Back 2

Structural Support

Medium for nutrient/waste exchange

Defense/Protection Body

Energy Storage

Repair after injury

Front 3

Preprocollagen compostition

Back 3

Glycine, Proline, Hydroxyproline, hydroxylysine

Front 4

Collagen Formation

Back 4

3 preprocollagen molecules align and from a helical procollagen molecule

At secretion procollagen peptidases remove terminal protein making tropocollagen

Tropocollagen polymerizes to form fibrils

Fibrils polymerize to form collagen fibers

Front 5

Reticular fibers are covered by

Back 5

Glycoprotein coat

Front 6

Do Elastic Fibers have hydroxylysine

Back 6

No

Front 7

Desmosine

Back 7

For lysine molecules of different elastin chains covalently bond. Imparts elasticity

Front 8

Fibrillin

Back 8

Forms microfibrils surrounding elastin

Front 9

Formation of Elastic Fibers

Back 9

Fibrillin microfibrils laid down

Elastin deposited on the microfibrils

Front 10

Enzyme that breaks down elastin

Back 10

Pancreatic elastase

Front 11

Ground substance composition

Back 11

Water

Glycosaminoglycans (GAGs)

Proteoglycans

Multiadhesive glycoproteins

Front 12

Function of Ground substance

Back 12

Lubricates and acts as a barrier to invaders

Front 13

How do GAGs resist compression

Back 13

Negative charge attracts water and repels each other making things slippery

Front 14

Aggrecan

Back 14

Proteoglycan responsible for the gel state of the EMC and acts as diffusion barrier

Front 15

Glycoprotein function

Back 15

Allow cell and other things to attach to ECM. Cells attach through integrins

Mediate interactions between cells

Front 16

Examples of Glycoproteins (2)

Back 16

Laminin and Fibronectin

Front 17

Ehlers-Danlos Syndrome

Back 17

Stops Hydroxylation of Lysine and inhibits Proteases cleaving ends

Leads to increased Skin elasticity and potential eyeball rupture

Front 18

Dermatosparaxis

Back 18

Inhibits proteases the cleave ends

Thin skin

Front 19

Hereditary Equine Regional Derma Asthenia (HERDA)

Back 19

Linked to protein mutations in procollagen chaperoning

Specific for dermal layer

Front 20

Marfan Syndrome

Back 20

Reduced amount of fibrillin and therefore elastic fibers

Front 21

Cutaneous Mucinosis

Back 21

Makes more GAGs and hyalonic acid

Only in dermis

Increases hyaluronian synthesis enzyme

Front 22

3 characteristics of a Tendon

Back 22

DRCT

Boxcar effect/arrangement

Basophilic streaming