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18 Cards in this Set

  • Front
  • Back
Degenerative Joint Disease
A.K.A. osteoarthritis
Most common form of arthritis
Characterized by progressive erosion of articular cartilage
Bony outgrowths, osteophytes, may occur
Hip, knees, and vertebrae are the major sites of involvement
Rheumatoid Arthritis
Chronic, systemic inflammatory disorder
Sustained by auto-immune reaction
The mass that is produced is the PANNUS
Ultimately, obliteration of the joint space and FUSION
Rheumatoid nodules occur in 25% (esp. children)
Crystal Induced Joint Disease
Most commonly is gout (monosodium urate)
Can be pseudogout (calcium pyrophosphate dihydrate)
Provoked by precipitated crystals in the synovium
Decreased bone mass to below normal
Condition of defective matrix mineralization
Associated with nutritional deficit or Vit. D problems
Undermineralized bone is formed
Known as Rickets in children
Reduction in the mass of bone per unit volume (SO, decr. density)
Micro-architectural deterioration of bone (porosity)
Bone resorption exceeds bone formation
The most common metabolic bone disease
Type I Osteoporosis
Occurs primarily in post-menopausal women
Related to loss of estrogen --> Inc. recruitments of osteoclasts
Fractures typically occur in trabecular bone
Distal forearm, vertebral bodies
Type II Osteoporosis
Associated with aging, in BOTH men and women
Associated with progressively fewer osteoblasts
Loss of bone on BOTH trabecular and cortical sites
Fractures common in the femur, femoral neck, proximal tibia, pelvis
Idiopathic Osteoporosis
Seen in the young
Vertebral regions most prone to osteoporosis
Mid-lower thoracic

Fracture of vertebrae is most prominent in anterior portion
Produces flattening and wedging
Shortening and kyphosis of the spine
Paget Disease
Osteolytic --> Osteoclastic/blastic --> Osteosclerotic
Appears to involve both environmental and genetic factors
Begins to appear at 40 years
Slight male preponderance
Pelvis > skull > femur > spine > tibia
Haphazard mosaic pattern in bone
Cortex is thickened but NOT strengthened
A.K.A. Marble Bone Disease
Rare hereditary disease
Osteoclast function is defective
Usually involves the head of the femur
Subchondral pain and fracture
40-80% have bilateral disease in 10 yrs
Necrosis of bone marrow results in collapse of cartilage
Attempts at repair never restore normal contour
Inflammation of the bone and marrow
Due to Staph or Mycobacteria
Different types of fractures
Complete vs. Incomplete
Closed vs. Compound
Comminuted vs. Displaced
Fibrous Cortical Defect
NOT a neoplasm
20 - 50% of normal kids
Gradually disappears by the end of teens
Only important because if they grow large, they weaken bone
Most common malignant neoplasm of bone
Tumor cells capable of making osteoid
Most common in young men
Responds to chemo
5-yr of > 60% using chemo and limb salvage
Ewing's Sarcoma
Nearly all show TRANSLOCATION t(11;22)
Most common in the young (2/3 < 20 yo)
More common in boys than girls (2:1)
5-yr. of 60 - 75% with chemo, radio, and surgery