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22 Cards in this Set

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Beta Adrenergic Blocking Drugs
Prevent Beta adrenergic receptors from responding to adrenergic nerve impulses, neurotransmitters or catecholamines
Beta Receptor Blockade
has an inhibitory effect on the cardiovascular system;, resulting in decreased HR, decreased force of myocardial contraction,and slowed electrical conductivity thru AV node, decreased automaticity of ectopic pacemakers, decreased CO at rest and exercise, decreased BP in supine and standing positions, esp ppl having HTN
Chronic use of Beta Adrenergic Blockers
associated c increased VLDL and decreased HDL. Poses a threat to ppl having cardiovas diseases. Beta Blkade also results in decreased renin secretion, decreased aqueous humor producton and portal vein pressure
Adverse Effects of Beta 2 blockers
bronchoconstriction, less effective glucose metab, tachycardia caused by hypoglycemia may be masked, increased tone of smooth muscles in GI tract, urinary bladder and uterus
Levolbunolol/ Betagan
Metripranolol/ Optipranolol
The only beta blockers used to tx Glaucoma
Propranolol/Inderal
prototype for Beta adrenergic Blocking drugs. The oldest and most extens studied beta blkr. Tx HTN, dysrhythm, angina pectoris, MI hypertrophic obstructive cardiomyopathy, pheochromocytoma, disecting aortic aneurysms, hyperthyroidism. Also used for Migraines, but unknown mech of axn. Good for alcoholics
Isoproterenol/Isuprel
Ax only on Beta receptors. Synthetic Catecholamine. Usage: Card stim n Hrt Blk, and cardiogenic shk. Bronchodilator (altho beta 2 preferred), card dysrhym, shk
Non Selective Beta Blkrs
Levobunolol, metipranolol, penbutolol, nadolol, pindolol, propranolol, solatol, timolol (beta 1&2 blkd so adverse effects wld be bronchoconstriction,and interference with glycogenisis- not good for DM)
Cardioselective (Beta 1)
Acebutolol, atenolol, betaxolol, bisoprolol, esmolol, metoprolol

Preferred with asthma, periph disorders
Sotalol
Exerts and Antidysrhym effect by blking K+ channel in cell membranes, thereby prolonging repolarization and refractory period of the HRT. Used to tx life threatening ventric dysrhytm and mntn norm sinus.
BBW strict cardiac monit for 3 days aft initiation. Creat clear necc before use
Esmolol
Recomm BABA of choice for perioperative period. It is cardioselective, can be given IV and has rapid onset of axn. Reduces CO, controls postop and intraop tach and HTN
When to use BABA's (-olols)
Cardiovasc disorders- angina pectoris, cardiac tachy, dysrhym, HTN, MI, HF, Hypertropic subaortic stenosis, migraines and glaucoma
BABA's
Levobunolol, metripranolol, propranolol, pindolol, nadolol, sotalol, timolol, Acebutolol, Atenolol, Betaxolol, bisoprolol, esmolol, metaprolol (lopress- MI)
Ephedrine
Mixed Acting Adrenergic- Alpha and betas= release of norepi
axn less potent but longer acting than epinephrine. produces more cns stim than other adrenergics. orally OR parentarally. Oral- fx in 1 hr, duration 3-5; SQ fx in 20 min, duration 60 min; IM fx 10-20 mins, duration less than 60 min
Epinephrine
Adrenergic Prototype (Adrenalin)targets Alpha 1 and all betas. at high doses, alpha 1 fx predom. drug of choice for relieving acute bronchospasm and laryngeal edema of anaphylactic shk. For cardiac arrest (cpr)
NOT given PO
Rapid but short acting. syncope in inf and chldn
What do Alpha 1 receptors do
Vasoconstrict
bld vess, kidney, intest smooth mus, liver, GU smooth mus, Eye, preg uterus.
pressor efct- incr BP
Beta receptors, where are they
dilation
beta 1- heart and Kidney
beta 2 bronchioles, bld vss, gi tract (decrease motility) liver, UGT/bldr, preg uterus (relaxation)
beta3 adipose tiss Gi tract
Beta2 Adrenergic
bronchodilation, vasodilation, increased bld flw to hrt, brain, skeletal muscles. Glycogenolysis in liver, decreased pancreatic insulin secretion, resulting in hyperglycemia. relaxation of uterus smooth muscle (activation can prevent prem labor), urinary bldr and GI tract relaxation
Beta 1 axn
increased everything on heart
(inotropic, chronotropic and dromotropic) and increased renin secretion
sweat glands
are under sympathetic control, but the postganglionic neurotransmitter is ACETYLCHOLINE
Neurotransmitter in Parasympathetic Nervous system
Acetylcholine, -cholinergics
neurotrans in brn, ans, and neuromusc jxns
nicotinic receptors
nicotinic N -located in autonomic ganglia and adrenal medulla. enhanced nerve impulse at all para and symp ganglia and release of epi frm adren medulla.
nicotinic M- at neuromusc jxns- cause musc contrac
nicotinic CNS at presynaptic nrv fibers n brain and spinal cord, promotes release of acetylcholine n cerebral cortex