3 Immunology - Lec 7 Antigen Presenting Cells

Front 1

What are the 3 most important antigen-presenting cells?

Back 1

1) dendritic cells
2) macrophage/monocyte
3) B-lymphocytes

Front 2

What are 6 things secreted once a toll like receptor is activated?

Back 2

1) cytokines: TNF alpha & IL-1

2) chemokines (chemotatic cytokines)

3) INF-alpha & beta (antivirals)

4) IL-6 stimulates bone marrow to increase WBC count

5) IL-12 activates TH1 & NK cells

6) IL-10 is the inhibitory cytokine to turn down response

Front 3

What are 3 functions of IL-1 & TNF-alpha?

Back 3

1) activate endothelial cells so leukocytes can adhere & roll & migrate

2) activate liver to release CRP

3) effect hypothalamus to create fever, depression, anorexia

Front 4

What do INF-alpha & INF-beta do?

Back 4

- antiviral cytokines

Front 5

What does IL-6 do?

Back 5

- stimulates bone marrow causing increased WBC count

Front 6

What does IL-12 do? What is special about it?

Back 6

- stimulates TH1 & NK cells

- bridges b/w innate & acquired immunity by stimulating T cells

Front 7

What does IL-10 do?

Back 7

- inhibitory cytokine - turns down immune response

Front 8

Once TLR on APC is activated they move to the lymph node to interact with ______

Back 8

- T-cells

- immature dendritic cell before interacted with antigen - then once it did & migrates to the lymph node it becomes a mature dendritic cell

Front 9

T cells only recognize foreign antigens when they are presented inside _________ molecules

Back 9

- MHC II

Front 10

The MHC area is on the _____ arm of the _____ chromosome. It encodes both classes. What are the alleles for MHC I? MHC II?

Back 10

- short arm

- 6th chromosome

- MHC I: A, B, C

- MHC II: DP, DQ, DR

Front 11

The _____ region on chromosomes is the most polymorphic system in biology

Back 11

- MHC

Front 12

________ is another name of MHC in humans

Back 12

- HLA: human leukocyte antigen

Front 13

what is the major reason for graft rejection?

Back 13

- MHC (HLA) proteins are antigens on transplanted tissue

- recognized by recipient's immune response & attacked --> causes transplant rejection

Front 14

Every individual inherits ___ haplotypes of MHC molecules. A couple could have ____ children with different haplotypes.

Back 14

- 2

- 4

Front 15

every cell in the body has which MHC complex? which cell is an exception? What does the structure of this molecule look like & why is this useful for dying cells?

Back 15

- MHC I

- red cells are an exception

- has one long chain with alpha regions & an associated beta-microglobulin

- can measure beta-microglobulin in blood to see if cells are dying

Front 16

MHC II are only found on what kinds of cells? What does the structure of these molecules look like?

Back 16

- APCs

- one beta & one alpha chain

Front 17

Both Class I and Class II MHC molecules have a __________. For MHC I who makes this groove?

Back 17

- peptide binding cleft

- alpha chain (b/c beta microglobulin is just associated, not part of binding)

Front 18

Ankylosing spondylitis associated with which HLA?

Back 18

- HLA B27

Front 19

Narcolepsy is associated with what?

Back 19

- DQ1 & DR2 (MHC II)

Front 20

type 1 diabetes is associated with what?

Back 20

- DR3 or DR4 (MHC II)

Front 21

rheumatoid arthritis is associated with what?

Back 21

- HLA DR4