The Difference Between Antibiotic Creams And Ointments

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Antibiotic creams, also known as topical ointments are preparations designed to fight bacteria on the skin. The main difference between antibiotic creams and ointments is the oil to water ratio. For instance, ointments contain an average of 80% oil and 20% water while creams contain a relatively lower oil to water ratio. This is why ointments tend to feel greasier and stickier than creams. We have chosen three antibiotic creams and three antibiotic ointments in order to find out which antimicrobial agents each one contains, and compare how effective each one is.
Bactroban cream is an antibiotic that is used topically, and is primarily effective against gram-positive bacteria. Mupirocin calcium, the active antibacterial agent, is produced by
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Due to its active antibacterial agent and its unique chemical structure (C31H48O6), the Fusidic acid acts as a bacterial protein synthesis inhibitor that prevents the growth and replication of the bacteria. The spectrum of antibacterial activity is primarily effective against gram-positive bacteria, Streptococci, Coryne-bacteria, Neisseria, Moraxella, Legionella pneumophila, and Bacteroides fragilis by preventing the turnover of elongation factor G (EF-G) from the ribosome. It is inactive on most gram-negative bacteria. Fucidin is generally prescribed to treat common skin infections as impetigo contagiosa, angular cheilitis, infected dermatitis and erythrasma and secondary skin infections such as infected wounds and infected burns. The Fucidin ointment has the same effectiveness as the the cream however it contains sodium fusidate, which is the sodium salt of Fusidic acid. Fucidin is well tolerated, therefore it has a low frequency of hypersensitivity …show more content…
It consists of a combination of two antibacterial agents, bacitracin (C66H101N17O16SZn) and neomycin (C23H46N6O13). Bacitracin is mainly active against gram-positive organisms, such as Clostridia, Corynebacterium Diphtheriae, Hemolytic streptococci, Staphylococci, Treponema. Bacitracin is also active on some gram-negative pathogens such as Haemophilus influenzae, Neisseria, in addition to Actinomycetes and Fusobacteria. Resistance to bacitracin is extremely uncommon. Meanwhile, neomycin acts on both gram-positive and gram-negative pathogens including staphylococci, Proteus, Enterobacter aerogenes, Klebsiella pneumoniae, Salmonellae, shigallae, Haemophilus influenza, Pasteuerella, Neisseria meningitides, Vibro cholera, Bordetella pertussis, Bacillus anthracis, Corynebacterium diptheriae, Streptococcus faecalis, Listeria monocytogenes, Escherichia coli Mycobacterium tuberculosis, Borrelia and Leptospira interrogans (L. icterohemorrhagicae). Despite having the combination of bacitracin with neomycin provide a broad-spectrum effect, they do not cover Nocardia, Pseudomonas, fungi and viruses. Overall, tissue tolerance of baneocin is excellent however with patients undergoing long long-term treatment may develop allergic reactions such as dry skin, redness, skin rashes and

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