The Difference Between Antibiotic Creams And Ointments

Good Essays
Antibiotic creams, also known as topical ointments are preparations designed to fight bacteria on the skin. The main difference between antibiotic creams and ointments is the oil to water ratio. For instance, ointments contain an average of 80% oil and 20% water while creams contain a relatively lower oil to water ratio. This is why ointments tend to feel greasier and stickier than creams. We have chosen three antibiotic creams and three antibiotic ointments in order to find out which antimicrobial agents each one contains, and compare how effective each one is.
Bactroban cream is an antibiotic that is used topically, and is primarily effective against gram-positive bacteria. Mupirocin calcium, the active antibacterial agent, is produced by
…show more content…
Due to its active antibacterial agent and its unique chemical structure (C31H48O6), the Fusidic acid acts as a bacterial protein synthesis inhibitor that prevents the growth and replication of the bacteria. The spectrum of antibacterial activity is primarily effective against gram-positive bacteria, Streptococci, Coryne-bacteria, Neisseria, Moraxella, Legionella pneumophila, and Bacteroides fragilis by preventing the turnover of elongation factor G (EF-G) from the ribosome. It is inactive on most gram-negative bacteria. Fucidin is generally prescribed to treat common skin infections as impetigo contagiosa, angular cheilitis, infected dermatitis and erythrasma and secondary skin infections such as infected wounds and infected burns. The Fucidin ointment has the same effectiveness as the the cream however it contains sodium fusidate, which is the sodium salt of Fusidic acid. Fucidin is well tolerated, therefore it has a low frequency of hypersensitivity …show more content…
It consists of a combination of two antibacterial agents, bacitracin (C66H101N17O16SZn) and neomycin (C23H46N6O13). Bacitracin is mainly active against gram-positive organisms, such as Clostridia, Corynebacterium Diphtheriae, Hemolytic streptococci, Staphylococci, Treponema. Bacitracin is also active on some gram-negative pathogens such as Haemophilus influenzae, Neisseria, in addition to Actinomycetes and Fusobacteria. Resistance to bacitracin is extremely uncommon. Meanwhile, neomycin acts on both gram-positive and gram-negative pathogens including staphylococci, Proteus, Enterobacter aerogenes, Klebsiella pneumoniae, Salmonellae, shigallae, Haemophilus influenza, Pasteuerella, Neisseria meningitides, Vibro cholera, Bordetella pertussis, Bacillus anthracis, Corynebacterium diptheriae, Streptococcus faecalis, Listeria monocytogenes, Escherichia coli Mycobacterium tuberculosis, Borrelia and Leptospira interrogans (L. icterohemorrhagicae). Despite having the combination of bacitracin with neomycin provide a broad-spectrum effect, they do not cover Nocardia, Pseudomonas, fungi and viruses. Overall, tissue tolerance of baneocin is excellent however with patients undergoing long long-term treatment may develop allergic reactions such as dry skin, redness, skin rashes and

Related Documents

  • Decent Essays

    Cephalosporin is another antibiotic that works against gram positive bacteria as they prevent the bacteria walls from synthesis. Sulfamethoxazole and Sulfisoxazole are antibiotics that are also effective in working against gram positive bacteria.…

    • 1140 Words
    • 5 Pages
    Decent Essays
  • Decent Essays

    Antimicrobial activity of the drug Tal Sindoor can be tested in 2 methods i.e. Gradient plate technique and Kirby-bauer method. Tal Sindoor has an effective anti-microbial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Streptococcus mutans and Candida albicans. But K. pneumoniae and A. Baumannii are resistant to Tal Sindoor like they are with other…

    • 932 Words
    • 4 Pages
    Decent Essays
  • Decent Essays

    Bacteria do not contain a nucleus; therefore they’re prokaryotic, instead they contain a DNA strand. Bacteria are identified into five groups: cocci, bacilli, spirilla, vibrios, and spirochaetes, which are classified by shape. Antibiotics are created to fight off bacteria related illnesses, some bacteria can evolve to become antibiotic resistant. Through a complex process, some bacteria that survive the antibiotic, will form newly antibiotic resistance bacteria. E. coli (Escherichia coli 0157:H7) is a type of bacteria that can be harmful to humans, which causes severe bloody diarrhea, abdominal cramps, and a slight fever.…

    • 1067 Words
    • 4 Pages
    Decent Essays
  • Decent Essays

    For instance penicillin is known to be effective against gram positive bacteria including Staphylococcus aureus of which during its activity forms surface protein that binds and leads to the osmotic lysis (Willey et al, 2011 page832). However, there are some emergences of bacteria resistance to penicillin causing pathogenic Staphylococcus aureus infections know as Methicillin – resistant Staphylococcus aureus (MRSA) (Chaitow, 1998) commonly found in hospitals. The results showed that Ciprofloxacin (C) was effective against S. aureus solid proof backing the literature that the drug has capabilities against gram-negative species better than Gram –positive (Heritage et al, 1999). The diameter of inhibition zone (21mm) was larger than the standard diameter given as >14. There are new strain resistant caused by altercations in topoisomerase(Willey, et al 2008).…

    • 2232 Words
    • 9 Pages
    Decent Essays
  • Decent Essays

    Compound 3b Lab Report

    • 889 Words
    • 4 Pages

    Abstract 6- bromo-2-(4-chlorophenyl)quinazolin-4(3H)-one derivatives 2-7 were synthesized.. The synthesized compounds were evaluated for their anti-microbial activity using the agar diffusion technique . The tested compounds were evaluated against, Gram +ve bacteria , Gram -ve bacteria, Yeast and Filamentous Fungus. Minimum inhibitory concentration (MIC) was made in vitro for compounds which showed antimicrobial activity. Compound 3b has broad spectrum activity against Gram +ve bacteria, Gram -ve bacteria, Yeast and Filamentous Fungus with MICs 150, 150, 75, 312, 625 and 625 µg/mL against (Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 3555, Escherichia coli ATCC 23282 Pseudomonas aeruginosa ATCC 10145, Candida albicans IMRU…

    • 889 Words
    • 4 Pages
    Decent Essays
  • Decent Essays

    An infectious disease is pathogenic microorganisms, like bacteria, viruses, parasites or fungi that cause diseases by spread, directly or indirectly, from one person to another. One infectious disease is Clostridium difficile, a nasty bacterium that affects the digestive system, specifically the colon. A disease that can start of pretty mild and lead to life-threatening inflammation of the colon. Clostridium difficile is a bacterial infection in the digestive system which has the same symptoms as colitis (inflammation of the colon). C. difficile is bacillus shaped, gram-stained, an endospore former and thrives off in the absence of oxygen.…

    • 953 Words
    • 4 Pages
    Decent Essays
  • Decent Essays

    Pathogenic Bacteria

    • 1075 Words
    • 4 Pages

    It includes Mucus membrane, secretory immunoglobulin A (sIgA), macrophages and antigen presenting cells (APCs). A good example of primary innate immune defense is the mucus membrane, which eliminates bacterial adhesion by ciliary movement or mucus in the upper respiratory tract (Fedtke et al., 2004). Bordetella pertussis is a well-known example of the strategy that disables the clearance role of ciliary epithelial cells in the upper respiratory tract. This bacterium releases tracheal cytotoxin, which impairs ciliary movement and leads to the colonization of the microorganism (Hornef et al., 2002). SIgA covers the mucus membrane, and it is part of the primary defenses.…

    • 1075 Words
    • 4 Pages
    Decent Essays
  • Decent Essays

    Oregano Case Study

    • 1165 Words
    • 5 Pages

    It contains nutrients like Fiber, Calcium, Iron, Potassium, Vitamin E and Vitamin K. Oregano is also a rich source of dietary antioxidants, which help protect the cells against the effects of free radicals. Oregano also Contains carvacrol which is an antibacterial property. The herb has shown success in defeating strains of the food pathogen (Listeria monocytogenes). Oregano can also protect humans from one of the difficult diseases to defeat which is cancer. A Research published in the journal PLoS ONE in 2013 suggested that “oregano exhibits anticancer activity.” The scientists concluded that Origanum majorana could help prevent and treat cancer by slowing or preventing its progression.…

    • 1165 Words
    • 5 Pages
    Decent Essays
  • Decent Essays

    Antiseptics are used to treat and prevent infection on skin, but many antiseptic products use different active ingredients to kill or slow the growth of bacteria. Several commonly used antiseptics contain active ingredients include isopropyl alcohol, iodine, chlorohexidine gluconate, and hydrogen peroxide. The use for products with these ingredients also depends on the type of wound since certain active ingredients have different mechanisms for killing bacteria. However, a growing concern in modern medicine is how bacteria can become resistant to antimicrobial agents such as antiseptics. When bacteria is exposed to low concentrations of antimicrobial agents, some of the bacteria can survive and mutate to produce a better line of defense against…

    • 829 Words
    • 4 Pages
    Decent Essays
  • Decent Essays

    Gram Catalase Test Report

    • 1163 Words
    • 5 Pages

    Also, mannitol agar was used which isolates and detects gram-positive bacteria. As well as blood agar, which is a nutritive media with differential properties in respect to hemolysis. The catalase test indicated catalase production and the coagulase test indicated a lack clotting in the tube. These tests were used for…

    • 1163 Words
    • 5 Pages
    Decent Essays